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239764 Cycloheximide, High Purity - CAS 66-81-9 - Calbiochem

239764
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CAS #Empirical Formula
66-81-9C₁₅H₂₃NO₄

Prix & Disponibilité

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239764-100MG
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      Flacon en verre 100 mg
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      239764-1GM
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      Interrompu(e)
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          Bidon alu 1 gm
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          Description
          OverviewAntifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and a variety of other cell types including rodent macrophages. However, it inhibits DNA cleavage in rat thymocytes treated with Thapsigargin (Cat. No. 586005), methylprednisolone, and Ionomycin (Cat. Nos. 407950 and 407952). Rapidly destroyed in alkaline solutions. Also available as a 300 mM solution in DMSO (Cat. No. 508739).
          Catalogue Number239764
          Brand Family Calbiochem®
          References
          ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
          Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
          Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
          Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
          Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
          Waring, P. 1990. J. Biol. Chem. 265, 14476.
          Product Information
          CAS number66-81-9
          FormWhite solid
          Hill FormulaC₁₅H₂₃NO₄
          Chemical formulaC₁₅H₂₃NO₄
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationCycloheximide, High Purity, CAS 66-81-9, is an antifungal antibiotic that inhibits protein synthesis in eukaryotes. Interacts directly with a translocase and interferes with the translocation step.
          Biological Information
          Primary TargethFKBP12
          Primary Target K<sub>i</sub>3.4 µM
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSMA4375000
          Safety Information
          R PhraseR: 28-40-51/53-61

          Very toxic if swallowed.
          Limited evidence of a carcinogenic effect.
          Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
          May cause harm to the unborn child.
          S PhraseS: 45-53-61

          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Avoid exposure - obtain special instructions before use.
          Avoid release to the environment. Refer to special instructions/safety data sheet.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Cycloheximide, High Purity - CAS 66-81-9 - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Cycloheximide, High Purity - CAS 66-81-9 - Calbiochem Certificats d'analyse

          TitreNuméro de lot
          239764

          Références bibliographiques

          Aperçu de la référence bibliographique
          Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
          Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
          Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
          Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
          Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
          Waring, P. 1990. J. Biol. Chem. 265, 14476.

          Brochure

          Titre
          Tools and Tips for Analyzing Apoptosis

          Citations

          Titre
        • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.
        • Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision29-April-2008 RFH
          DescriptionAntifungal antibiotic that does not inhibit several species of pathogenic bacteria at 100 µg/ml. Inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFkBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells, and a variety of other cell types, including rodent macrophages. Inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.
          FormWhite solid
          CAS number66-81-9
          RTECSMA4375000
          Chemical formulaC₁₅H₂₃NO₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityChloroform, Ethanol, and Methanol
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Merck USA index14, 2728
          ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
          Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
          Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
          Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
          Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
          Waring, P. 1990. J. Biol. Chem. 265, 14476.
          Citation
        • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.