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239777 Cyclophilin A, Human, Recombinant, E. coli - CAS 95076-93-0 - Calbiochem

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Peptidylproline cis-trans-Isomerase

Primary Target: Catalyzes the cis-trans-isomerization of X-Pro peptide bonds
239777
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239777-100UG
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      Description
      OverviewRecombiant, human cyclophilin A expressed in E. coli. An ubiquitous enzyme that catalyzes the cis-trans-isomerization of X-Pro peptide bonds. Binds to proteins and acts as a chaperone in protein folding. Incorporates into HIV-1 virons and is believed to be essential for viral infectivity. Cyclophilin binds to the immunosuppressant Cyclosporin A (Cat. No. 239835). This complex then binds calcineurin (PP2B) and inhibits its phosphatase activity.
      Catalogue Number239777
      Brand Family Calbiochem®
      SynonymsPeptidylproline cis-trans-Isomerase
      References
      ReferencesFruman, D.A., et al. 1994. FASEB J. 8, 391.
      Galat, A. 1993. Eur. J. Biochem. 216, 689.
      Kunz, J., and Hall, M.M. 1993. Trends Biochem. Sci. 18, 334.
      Luban, L., et al. 1993. Cell 73, 1067.
      Holzman, T.F., et al. 1991. J. Biol. Chem. 266, 2474.
      Kofron, J.L., et al. 1991. Biochemistry 30, 6127.
      Product Information
      CAS number1185-53-1, 95076-93-0
      ATP CompetitiveN
      EC number5.2.1.8
      FormLiquid
      FormulationIn 20 mM Tris-HCl, pH 7.8.
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCatalyzes the cis-trans-isomerization of X-Pro peptide bonds
      Purity≥90% by SDS-PAGE
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 24/25-36

      Avoid contact with skin and eyes.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsLoss of protein may occur at high dilutions due to adsorption to container surfaces.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cyclophilin A, Human, Recombinant, E. coli - CAS 95076-93-0 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      239777

      Références bibliographiques

      Aperçu de la référence bibliographique
      Fruman, D.A., et al. 1994. FASEB J. 8, 391.
      Galat, A. 1993. Eur. J. Biochem. 216, 689.
      Kunz, J., and Hall, M.M. 1993. Trends Biochem. Sci. 18, 334.
      Luban, L., et al. 1993. Cell 73, 1067.
      Holzman, T.F., et al. 1991. J. Biol. Chem. 266, 2474.
      Kofron, J.L., et al. 1991. Biochemistry 30, 6127.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-December-2008 RFH
      SynonymsPeptidylproline cis-trans-Isomerase
      DescriptionRecombiant, human cyclophilin A expressed in E. coli. An ubiquitous enzyme that catalyzes the cis-trans-isomeration of X-Pro-peptide bonds. Binds to proteins and acts as chaperone in protein folding. Incorporates into HIV-1 virons and is believed to be essential for viral infectivity. Cyclophilin is characterized by its binding to the immunosuppressant cyclosporin A. This complex then binds calcineurin (PP2B) and inhibits its phosphatase activity.
      FormLiquid
      FormulationIn 20 mM Tris-HCl, pH 7.8.
      Concentration Label Please refer to vial label for lot-specific concentration
      CAS number1185-53-1, 95076-93-0
      EC number5.2.1.8
      Purity≥90% by SDS-PAGE
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsLoss of protein may occur at high dilutions due to adsorption to container surfaces.
      Toxicity Standard Handling
      ReferencesFruman, D.A., et al. 1994. FASEB J. 8, 391.
      Galat, A. 1993. Eur. J. Biochem. 216, 689.
      Kunz, J., and Hall, M.M. 1993. Trends Biochem. Sci. 18, 334.
      Luban, L., et al. 1993. Cell 73, 1067.
      Holzman, T.F., et al. 1991. J. Biol. Chem. 266, 2474.
      Kofron, J.L., et al. 1991. Biochemistry 30, 6127.