500509 DNA Methyltransferase Inhibitor V, RSC133 - Calbiochem

500509
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical Formula
      C₁₈H₁₅N₃O₂

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      5005090001
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      Interrompu(e)
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          Flacon en verre 25 mg
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          Description
          OverviewA cell-permeable indolylacrylamido-benzamide compound that is reported to target Dnmt1 at the cofactor SAM-binding site and enhance the efficiency of iPSC production from both murine MEF (10 µM starting 5 d post KSOM viral infection) and human foreskin fibroblast (10 µM starting same day as or 5 d post KSOM viral infection) cultures with accompanying cellular Dnmt1 activity reduction, affecting hFF viability only at high concentrations (78% of control post 72 h 100 µM treatment). Also shown to help maintain H9 hESCs in undifferentiated state when cultured in unconditioned media (10 µM).

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number500509
          Brand Family Calbiochem®
          SynonymsID133, iPSC Induction Enhancer III, Reprogramming Stimulating Compound 133, DNA MTase Inhibitor V, (E)-3-(3-(1H-Indol-3-yl)acrylamido)benzamide
          References
          ReferencesLee, J., et al. 2012. Angew. Chem. Int. Engl. 51, 12509.
          Product Information
          FormLight yellow powder
          Hill FormulaC₁₈H₁₅N₃O₂
          Chemical formulaC₁₈H₁₅N₃O₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetDnmt1
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          DNA Methyltransferase Inhibitor V, RSC133 - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Références bibliographiques

          Aperçu de la référence bibliographique
          Lee, J., et al. 2012. Angew. Chem. Int. Engl. 51, 12509.

          Informations techniques

          Titre
          White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-January-2014 JSW
          SynonymsID133, iPSC Induction Enhancer III, Reprogramming Stimulating Compound 133, DNA MTase Inhibitor V, (E)-3-(3-(1H-Indol-3-yl)acrylamido)benzamide
          DescriptionA cell-permeable indolylacrylamido-benzamide compound that is reported to target Dnmt1 at the cofactor SAM-(S-adenosyl methionine) binding site and enhance the efficiency of iPSC production from both murine MEF (by 2.1-fold at 15 d post viral KOSM transduction with 10 µM RSC133 starting 5 d post viral infection) and human foreskin fibroblast (by 3.5- and 2.9-fold 15 d post viral KOSM transduction with 10 µM RSC133 starting same day as or 5 d post viral infection, respectively) cultures with accompanying cellular Dnmt1 activity reduction (by 38% lower in 15 d viral-transduced hiPSC cultures with 10 µM RSC133 starting on d 5 post viral infection), affecting hFF viability only at high concentrations (102% and 78% of control after 72 h incubation with 50 and 100 µM RSC133, respectively, by MTT assays). Also shown to help maintain H9 hESCs in undifferentiated state when cultured in unconditioned media (17% vs 53% drop in AP+ colonies in 6 d UM cultures, respectively, with or without 10 µM RSC133).
          FormLight yellow powder
          Chemical formulaC₁₈H₁₅N₃O₂
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml). Use only fresh DMSO for reconstitution.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesLee, J., et al. 2012. Angew. Chem. Int. Engl. 51, 12509.