260010 Demethylasterriquinone B1 - CAS 78860-34-1 - Calbiochem

260010
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical FormulaCAS #
      C₃₂H₃₀N₂O₄ 78860-34-1

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      260010-5MG
      Récupération des données relatives à la disponibilité...
      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
          Pour le restant : Nous vous tiendrons informé
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          Ampoule plast. 5 mg
          Prix en cours de récupération
          Le prix n'a pas pu être récupéré
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          Description
          OverviewA cell-permeable unsymmetrical bis-indolylquinone insulin mimic with anti-diabetic activity in animal models. Selectively stimulates insulin receptor (IR) tyrosine kinase activity (EC50 ~ 6 µM in CHO•IR cells), while showing little effect towards IGF-1R, EGFR, or PDGFR. Also acts as an agonist for the neurotrophin receptors TrkA, B, and C in both cortical neurons and dorsal root ganglion neurons (~ 20 µM). DMAQ-B1 and insulin show differential effects on cellular gene expression profiles and DMAQ-B1 is a more selective agonist than insulin for the IR-mediated activation of PI-3 kinase/Akt pathway.
          Catalogue Number260010
          Brand Family Calbiochem®
          SynonymsL-783,281, DMAQ-B1, DAQ B1, 2-[2-(1,1-Dimethylallyl)-1H-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methylbut-2-enyl)-1H-indol-3-yl][1,4]benzoquinone, 2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-3-yl]-6-[2-(1,1-dimethyl-allyl)-1H-indol-3-yl]-[1,4]benzoquinone
          References
          ReferencesWebster, N.J., et al. 2003. Chembiochem 4, 379.
          Pirrung, M.C., et al. 2002. J. Org. Chem. 6, 23.
          Westerlund, J., et al. 2002. Diabetes 51, S50.
          Roper, M.G., et al. 2002. Diabetes 51, S43.
          Air, E.L., et al. 2002. Nat. Med. 8, 179.
          Wilkie, N., et al. 2001. J. Neurochem. 78, 1135.
          Salituro, G.M., et al. 2001. Recent Prog. Horm. Res. 56, 107.
          Liu, K., et al. 2000. J. Med. Chem. 43, 3487.
          Zhang, B., et al. 1999. Science 284, 974.
          Product Information
          CAS number78860-34-1
          ATP CompetitiveN
          FormBluish black solid
          Hill FormulaC₃₂H₃₀N₂O₄
          Chemical formulaC₃₂H₃₀N₂O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetInsulin receptor (IR) tyrosine kinase activity
          Primary Target IC<sub>50</sub>EC50 ~ 6 µM stimulating insulin receptor (IR) tyrosine kinase activity in CHO•IR cells
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Demethylasterriquinone B1 - CAS 78860-34-1 - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Demethylasterriquinone B1 - CAS 78860-34-1 - Calbiochem Certificats d'analyse

          TitreNuméro de lot
          260010

          Références bibliographiques

          Aperçu de la référence bibliographique
          Webster, N.J., et al. 2003. Chembiochem 4, 379.
          Pirrung, M.C., et al. 2002. J. Org. Chem. 6, 23.
          Westerlund, J., et al. 2002. Diabetes 51, S50.
          Roper, M.G., et al. 2002. Diabetes 51, S43.
          Air, E.L., et al. 2002. Nat. Med. 8, 179.
          Wilkie, N., et al. 2001. J. Neurochem. 78, 1135.
          Salituro, G.M., et al. 2001. Recent Prog. Horm. Res. 56, 107.
          Liu, K., et al. 2000. J. Med. Chem. 43, 3487.
          Zhang, B., et al. 1999. Science 284, 974.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-June-2008 RFH
          SynonymsL-783,281, DMAQ-B1, DAQ B1, 2-[2-(1,1-Dimethylallyl)-1H-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methylbut-2-enyl)-1H-indol-3-yl][1,4]benzoquinone, 2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-3-yl]-6-[2-(1,1-dimethyl-allyl)-1H-indol-3-yl]-[1,4]benzoquinone
          DescriptionA cell-permeable unsymmetrical bis-indolylquinone insulin mimic with anti-diabetic activity in animal models. Selectively stimulates insulin receptor (IR) tyrosine kinase activity (EC50 ~6 µM in CHO•IR cells), while showing little effect towards IGF-1R, EGFR, or PDGFR. Also acts as an agonist for the neurotrophin receptors TrkA, B, and C in both cortical neurons and dorsal root ganglion neurons (~20 µM). DMAQ-B1 and insulin show differential effects on cellular gene expression profiles and DMAQ-B1 is a more selective agonist than insulin for the IR-mediated activation of PI-3 kinase/Akt pathway.
          FormBluish black solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number78860-34-1
          Chemical formulaC₃₂H₃₀N₂O₄
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesWebster, N.J., et al. 2003. Chembiochem 4, 379.
          Pirrung, M.C., et al. 2002. J. Org. Chem. 6, 23.
          Westerlund, J., et al. 2002. Diabetes 51, S50.
          Roper, M.G., et al. 2002. Diabetes 51, S43.
          Air, E.L., et al. 2002. Nat. Med. 8, 179.
          Wilkie, N., et al. 2001. J. Neurochem. 78, 1135.
          Salituro, G.M., et al. 2001. Recent Prog. Horm. Res. 56, 107.
          Liu, K., et al. 2000. J. Med. Chem. 43, 3487.
          Zhang, B., et al. 1999. Science 284, 974.