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317641 Dipeptidylpeptidase IV Inhibitor III - CAS 866396-34-1 - Calbiochem

317641
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CAS #Empirical Formula
866396-34-1C₁₄H₂₀N₄O₂ • HCl

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317641-5MG
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      Description
      OverviewAn orally bioavailable dicyanopyrrolidine compound that acts as a slow-binding and active site-targeting inhibitor of DPP IV (IC50 = 106 nM using recombinant human DPP IV and 38, 69, 92, and 100 nM in inhibiting DPP IV activity in plasma from rat, human, monkey, and dog, respectively) with little activity against DPP II, DPP III, DPP VIII, DPP IX, FAP, or APP even at concentrations as high as 30 µM. Reported to lower blood DPP IV activity and augment GLP-1 response in dog and mouse in vivo.
      Catalogue Number317641
      Brand Family Calbiochem®
      Synonyms1-(((1-(Hydroxymethyl)cyclopentyl)amino)acetyl)-2,5-cis-pyrrolidinedicarbonitrile, HCl, DPP IV Inhibitor III
      References
      ReferencesWright, S.W., et al. 2006. J. Med. Chem. 49, 3068.
      Product Information
      CAS number866396-34-1
      FormWhite solid
      Hill FormulaC₁₄H₂₀N₄O₂ • HCl
      Chemical formulaC₁₄H₂₀N₄O₂ • HCl
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25-36/37/39

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Dipeptidylpeptidase IV Inhibitor III - CAS 866396-34-1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Dipeptidylpeptidase IV Inhibitor III - CAS 866396-34-1 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      317641

      Références bibliographiques

      Aperçu de la référence bibliographique
      Wright, S.W., et al. 2006. J. Med. Chem. 49, 3068.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-November-2008 RFH
      Synonyms1-(((1-(Hydroxymethyl)cyclopentyl)amino)acetyl)-2,5-cis-pyrrolidinedicarbonitrile, HCl, DPP IV Inhibitor III
      DescriptionAn orally bioavailable dicyanopyrrolidine compound that acts as a slow-binding and active site-targeting inhibitor of DPP IV (IC50 = 106 nM using recombinant human DPP IV and 38, 69, 92, and 100 nM in inhibiting DPP IV activity in plasma from rat, human, monkey, and dog, respectively) with little activity against DPP II, DPP III, DPP VIII, DPP IX, FAP, or APP even at concentrations as high as 30 µM. Reported to lower blood DPP IV activity and augment GLP-1 response in dog and mouse in vivo.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number866396-34-1
      Chemical formulaC₁₄H₂₀N₄O₂ • HCl
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityEthanol (20 mg/ml), H₂O (20 mg/ml), or PBS (20 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesWright, S.W., et al. 2006. J. Med. Chem. 49, 3068.