504684 Fenobam - CAS 57653-26-6 - Calbiochem

504684
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      Tableau de caractéristiques principal

      Empirical FormulaCAS #
      C₁₁H₁₁ClN₄O₂ 57653-26-6

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      5046840001
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      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
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          Flacon en verre 5 mg
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          Description
          OverviewA potent negative allosteric modulator highly selective for mGluR5 (IC50 = 87 nM; Kd = 54 nM and 31 nM at recombinant mGlu5 receptors of rat and human, respectively). Biologically active admitted orally or systematically. Frequently used for assessing the functional roles of mGlu5 receptors in a variety of brain functions (i.e. learning and memory, circadian rhythms, reward and decision making, and locomotion) and disorders (i.e. addition, depression, seizures, anxiety disorder, Parkinsons disease, Alzheimers disease, and Down syndrome). A leading therapeutic candidate for treatment of fragile X syndrome.
          Catalogue Number504684
          Brand Family Calbiochem®
          SynonymsN-(3-Chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea
          References
          ReferencesPorter, R., et al. 2005. J. Pharmacol. Exp. Ther. 315, 711.
          Jacob, W., et al. 2009. Neuropharmacology 57, 97.
          Berry-Kravis, E., et al. 2009. J. Medical Genetics. 46, 266.
          Watterson, R., et al. 2012. Psychopharmacol. 2012, 1.
          Simonyi, A., et al. 2010. Eur. J. Pharmacol. 639, 17.
          Westmark, J., et al. 2010. J. Alzheimer's Disease 20, 1009.
          Product Information
          CAS number57653-26-6
          FormWhite solid
          Hill FormulaC₁₁H₁₁ClN₄O₂
          Chemical formulaC₁₁H₁₁ClN₄O₂
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetmGlu₅ receptors
          Primary Target IC<sub>50</sub>87 nM
          Primary Target K<sub>i</sub>54 nM and 31 nM at recombinant mGlu₅ receptors of rat and human, respectively
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Fenobam - CAS 57653-26-6 - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Références bibliographiques

          Aperçu de la référence bibliographique
          Porter, R., et al. 2005. J. Pharmacol. Exp. Ther. 315, 711.
          Jacob, W., et al. 2009. Neuropharmacology 57, 97.
          Berry-Kravis, E., et al. 2009. J. Medical Genetics. 46, 266.
          Watterson, R., et al. 2012. Psychopharmacol. 2012, 1.
          Simonyi, A., et al. 2010. Eur. J. Pharmacol. 639, 17.
          Westmark, J., et al. 2010. J. Alzheimer's Disease 20, 1009.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-June-2013 JSW
          SynonymsN-(3-Chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea
          DescriptionA potent negative allosteric modulator highly selective for mGluR5 (IC50 = 87 nM; Kd = 54 nM and 31 nM at recombinant mGlu5 receptors of rat and human, respectively). Biologically active admitted orally or systematically. Frequently used for assessing the functional roles of mGlu5 receptors in a variety of brain functions (i.e. learning and memory, circadian rhythms, reward and decision making, and locomotion) and disorders (i.e. addition, depression, seizures, anxiety disorder, Parkinsons disease, Alzheimers disease, and Down syndrome). A leading therapeutic candidate for treatment of fragile X syndrome.
          FormWhite solid
          CAS number57653-26-6
          Chemical formulaC₁₁H₁₁ClN₄O₂
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesPorter, R., et al. 2005. J. Pharmacol. Exp. Ther. 315, 711.
          Jacob, W., et al. 2009. Neuropharmacology 57, 97.
          Berry-Kravis, E., et al. 2009. J. Medical Genetics. 46, 266.
          Watterson, R., et al. 2012. Psychopharmacol. 2012, 1.
          Simonyi, A., et al. 2010. Eur. J. Pharmacol. 639, 17.
          Westmark, J., et al. 2010. J. Alzheimer's Disease 20, 1009.