345888 Ghrelin Receptor Antagonist, JMV 2959 - Calbiochem

345888
Le prix n'a pas pu être récupéré
La quantité minimale doit être un multiple de
À la validation de la commande Plus d'informations
Vous avez sauvegardé ()
 
Demander le prix
Disponibilité limitéeDisponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service
      Voir les Prix & la Disponibilité

      Aperçu

      Replacement Information

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      345888-10MG
      Récupération des données relatives à la disponibilité...
      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
          Pour le restant : Nous vous tiendrons informé
          Nous vous tiendrons informé
          Contacter le Service Clients
          Contact Customer Service

          Flacon en verre 10 mg
          Prix en cours de récupération
          Le prix n'a pas pu être récupéré
          La quantité minimale doit être un multiple de
          À la validation de la commande Plus d'informations
          Vous avez sauvegardé ()
           
          Demander le prix
          Description
          OverviewA 1, 2, 4-triazole derived compound that acts as a potent ghrelin receptor (GHS-R1a) antagonist (IC50 = 32 nM in a binding assay, dissociation constant Kb = 19 nM). Shown to reduce hexarelin-induced food intake [hexarelin (80 µg/kg, cumulative food intake (g of food/100 g of body weight) at 6 h by acute administration (sc) of JMV 2959 (160 µg/kg)] in rats without affecting the basal food intake. Also suppresses ghrelin and fasting-induced food intake at the level of the central nervous system. Reported to suppress genes up-regulated by ghrelin. Does not affect intracellular Ca2+ mobilization.
          Catalogue Number345888
          Brand Family Calbiochem®
          Synonyms(R)-N-(2-(1H-indol-3-yl)-1-(4-(4-methoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)ethyl)-2-aminoacetamide hydrochloride, GHSR1a Antagonist, GH secretagogue receptor antagonist, JMV2959, Growth hormone secretagogue receptor antagonist
          References
          ReferencesMoulin, A., et al. 2013. Amino Acids 301.
          Mary, S., et al. 2012. Proc Natl Acad Sci USA 109, 8304.
          Salome, N., et al. 2009. Eur J Pharmacol. 612, 167,.
          Moulin, A., et al. 2007. J Med Chem 50, 579.
          Product Information
          FormBeige powder
          FormulationSupplied as a hydrochloride salt.
          Hill FormulaC₃₀H₃₂N₆O₂•HCl
          Chemical formulaC₃₀H₃₂N₆O₂•HCl
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetGhrelin receptor
          Primary Target IC<sub>50</sub>32 nM
          Purity≥97% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Ghrelin Receptor Antagonist, JMV 2959 - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Ghrelin Receptor Antagonist, JMV 2959 - Calbiochem Certificats d'analyse

          TitreNuméro de lot
          345888

          Références bibliographiques

          Aperçu de la référence bibliographique
          Moulin, A., et al. 2013. Amino Acids 301.
          Mary, S., et al. 2012. Proc Natl Acad Sci USA 109, 8304.
          Salome, N., et al. 2009. Eur J Pharmacol. 612, 167,.
          Moulin, A., et al. 2007. J Med Chem 50, 579.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-August-2014 JSW
          Synonyms(R)-N-(2-(1H-indol-3-yl)-1-(4-(4-methoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)ethyl)-2-aminoacetamide hydrochloride, GHSR1a Antagonist, GH secretagogue receptor antagonist, JMV2959, Growth hormone secretagogue receptor antagonist
          DescriptionA 1, 2, 4-triazole derived compound that acts as a potent ghrelin receptor (GHS-R1a) antagonist (IC50 = 32 nM in a binding assay, dissociation constant Kb = 19 nM). Shown to reduce hexarelin-induced food intake [hexarelin (80 µg/kg, cumulative food intake (g of food/100 g of body weight) at 6 h by acute administration (sc) of JMV 2959 (160 µg/kg)] in rats without affecting the basal food intake. Also suppresses ghrelin and fasting-induced food intake at the level of the central nervous system. Reported to suppress genes up-regulated by ghrelin. Does not affect intracellular Ca2+ mobilization.
          FormBeige powder
          FormulationSupplied as a hydrochloride salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₃₀H₃₂N₆O₂•HCl
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (100 mg/ml)or H₂O (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesMoulin, A., et al. 2013. Amino Acids 301.
          Mary, S., et al. 2012. Proc Natl Acad Sci USA 109, 8304.
          Salome, N., et al. 2009. Eur J Pharmacol. 612, 167,.
          Moulin, A., et al. 2007. J Med Chem 50, 579.