373275 Hh Signaling Antagonist XII, HPI-1 - CAS 599150-20-6 - Calbiochem

373275
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      Tableau de caractéristiques principal

      Empirical FormulaCAS #
      C₂₇H₂₉NO₆ 599150-20-6

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      373275-10MG
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      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
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          10 mg
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          Description
          OverviewA cell-permeable oxo-tetrahydroquinolinecarboxylate compound that acts as a downstream Hh (Hedgehog) pathway blocker, effectively inhibiting Gli-dependent transcription activity in both Sufu+/+ NIH 3T3 (shh-LIGHT2) and Sufu-/- fibroblast cultures (IC50 = 1.5 & 3 µM, respectively) in a manner similar to two other Hh downstream blockers, HPI-3 (Cat. No. 373276) and GANT-61 (Cat. No. 373401). However, only HPI-1, but not HPI-3 or GANT-61 (no effect at 30 µM), remains effective against Sufu-/- fibroblasts overexpressing Gli1 or Gli2 (IC50 = 6 & 4 µM, respectively). HPI-1 is also shown to inhibit the ligand-independent Hh pathway activation in SmoM2-expressing primary murine CGNPs (Cerebellar Granule Neuron Precursors) and NIH 3T3 (smoM2-LIGHT) cultures.
          Catalogue Number373275
          Brand Family Calbiochem®
          Synonyms2-Methoxyethyl-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate
          References
          ReferencesHyman, J.M., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 14132.
          Product Information
          CAS number599150-20-6
          FormPale yellow solid
          Hill FormulaC₂₇H₂₉NO₆
          Chemical formulaC₂₇H₂₉NO₆
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Hh Signaling Antagonist XII, HPI-1 - CAS 599150-20-6 - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Hh Signaling Antagonist XII, HPI-1 - CAS 599150-20-6 - Calbiochem Certificats d'analyse

          TitreNuméro de lot
          373275

          Références bibliographiques

          Aperçu de la référence bibliographique
          Hyman, J.M., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 14132.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-April-2011 RFH
          Synonyms2-Methoxyethyl-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate
          DescriptionA cell-permeable oxo-tetrahydroquinolinecarboxylate compound that acts as a downstream Hh (Hedgehog) pathway blocker, effectively inhibiting Gli-dependent transcription activity in both Sufu+/+ NIH 3T3 (shh-LIGHT2) and Sufu-/- fibroblast cultures (IC50 = 1.5 & 3 µM, respectively) in a manner similar to two other Hh downstream blockers, HPI-3 (Cat. No. 373276) and GANT-61 (Cat. No. 373401). However, only HPI-1, but not HPI-3 or GANT-61 (no effect at 30 µM), remains effective against Sufu-/- fibroblasts overexpressing Gli1 or Gli2 (IC50 = 6 & 4 µM, respectively). HPI-1 is also shown to inhibit the ligand-independent Hh pathway activation in SmoM2-expressing primary murine CGNPs (Cerebellar Granule Neuron Precursors) and NIH 3T3 (smoM2-LIGHT) cultures.
          FormPale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number599150-20-6
          Chemical formulaC₂₇H₂₉NO₆
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesHyman, J.M., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 14132.