220491 Sigma-AldrichInSolution™ Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem
The InSolution™ Chk2 Inhibitor II, also referenced under CAS 516480-79-8, controls the biological activity of Chk2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The InSolution™ Chk2 Inhibitor II, also referenced under CAS 516480-79-8, controls the biological activity of Chk2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
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Aperçu
Replacement Information |
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Tableau de caractéristiques principal
CAS # | Empirical Formula |
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516480-79-8 | C₂₀H₁₄ClN₃O₂ |
Prix & Disponibilité
Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
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220491-5MG |
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Flacon en verre | 5 mg |
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Description | |
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Overview | A cell-permeable and reversible benzimidazolo compound that acts as a potent and ATP-competitive inhibitor of Chk2 with an IC50 of 15 nM and a Ki of 37 nM. Displays ~ 1,000-fold greater selectivity over Cdk1/B and CK1 (IC50 = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC50 of 3 µM and 7.6 µM, respectively. The solid form of this compound (Cat. No. 220486) is also available. |
Catalogue Number | 220491 |
Brand Family | Calbiochem® |
Synonyms | 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide |
References | |
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References | Arienti, K. L., et al. 2005. J. Med. Chem. 48, 1873. |
Product Information | |
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CAS number | 516480-79-8 |
Form | Liquid |
Formulation | Supplied as a 25 mM (5 mg/550 µL) solution of Chk2 Inhibitor II (Cat. No. 220486) in DMSO. |
Hill Formula | C₂₀H₁₄ClN₃O₂ |
Chemical formula | C₂₀H₁₄ClN₃O₂ |
Hygroscopic | Hygroscopic |
Structure formula Image | |
Quality Level | MQ100 |
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Biological Information | |
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Purity | ≥95% by HPLC |
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Safety Information according to GHS |
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Product Usage Statements |
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Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
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Supplemental Information |
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Specifications |
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Documentation
InSolution™ Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem FDS
Titre |
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InSolution™ Chk2 Inhibitor II - CAS 516480-79-8 - Calbiochem Certificats d'analyse
Titre | Numéro de lot |
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220491 |
Références bibliographiques
Aperçu de la référence bibliographique |
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Arienti, K. L., et al. 2005. J. Med. Chem. 48, 1873. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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