420145 JAK3 Inhibitor VII, AD412 - CAS 796041-65-1 - Calbiochem

420145
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical FormulaCAS #
      C₂₃H₂₀ClN₃O 796041-65-1

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      420145-25MG
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      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
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          25 mg
          Prix en cours de récupération
          Le prix n'a pas pu être récupéré
          La quantité minimale doit être un multiple de
          À la validation de la commande Plus d'informations
          Vous avez sauvegardé ()
           
          Demander le prix
          Description
          OverviewA cell-permeable indole-3-propanamide immunosuppressant that is shown to selectively inhibit the kinase activity of JAK3 (by 81% and 36% at 90 and 30 µM, respectively) over that of JAK2 (by 29% and 0% at 90 and 30 µM, respectively) and reduce JAK1/3-dependent phosphorylations of Akt, STAT5a/b, and Erk1/2 in IL-2-stimulated CTL-L2 cells, but not JAK1/2-dependent STAT1 phosphorylation in INF-γ-stimulated U266 cultures. Reported to inhibit ConA-stimulated murine splenocytes and PHA-stimulated human PBL proliferation (IC50 = 17 and 25 µM, respectively) in vitro and be efficacious in ameliorating delayed hypersensitivity reaction in mice (by ~78% with a daily oral dose of 50 mg/kg) and in prolonging the survival of heart transplant-recipient rats (by >3-fold with 60 mg/kg/day, p.o.) in vivo.
          Catalogue Number420145
          Brand Family Calbiochem®
          SynonymsN-(Pyridin-4-yl)-3-[1-(4-chlorobenzyl)indol-3-yl]-propanamide
          References
          ReferencesCarbonnelle, D., et al. 2009. J. Pharm. Exp. Ther. 331, 710.
          Carbonnelle, D., et al. 2007. Eur. J. Med. Chem. 42, 686.
          Product Information
          CAS number796041-65-1
          FormWhite solid
          Hill FormulaC₂₃H₂₀ClN₃O
          Chemical formulaC₂₃H₂₀ClN₃O
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special Instructionsfollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          JAK3 Inhibitor VII, AD412 - CAS 796041-65-1 - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          JAK3 Inhibitor VII, AD412 - CAS 796041-65-1 - Calbiochem Certificats d'analyse

          TitreNuméro de lot
          420145

          Références bibliographiques

          Aperçu de la référence bibliographique
          Carbonnelle, D., et al. 2009. J. Pharm. Exp. Ther. 331, 710.
          Carbonnelle, D., et al. 2007. Eur. J. Med. Chem. 42, 686.

          Informations techniques

          Titre
          JAK/STAT Signaling Research Focus
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-April-2011 RFH
          SynonymsN-(Pyridin-4-yl)-3-[1-(4-chlorobenzyl)indol-3-yl]-propanamide
          DescriptionA cell-permeable indole-3-propanamide immunosuppressant that is shown to selectively inhibit the kinase activity of JAK3 (by 81% and 36% at 90 and 30 µM, respectively) over that of JAK2 (by 29% and 0% at 90 and 30 µM, respectively) and reduce JAK1/3-dependent phosphorylations of Akt, STAT5a/b, and Erk1/2 in IL-2-stimulated CTL-L2 cells, but not JAK1/2-dependent STAT1 phosphorylation in INF-γ-stimulated U266 cultures. Reported to inhibit ConA-stimulated murine splenocytes and PHA-stimulated human PBL proliferation (IC50 = 17 and 25 µM, respectively) in vitro and be efficacious in ameliorating delayed hypersensitivity reaction in mice (by ~78% with a daily oral dose of 50 mg/kg) and in prolonging the survival of heart transplant-recipient rats (by >3-fold with 60 mg/kg/day, p.o.) in vivo.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number796041-65-1
          Chemical formulaC₂₃H₂₀ClN₃O
          Purity≥95% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special Instructionsfollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesCarbonnelle, D., et al. 2009. J. Pharm. Exp. Ther. 331, 710.
          Carbonnelle, D., et al. 2007. Eur. J. Med. Chem. 42, 686.