489476 LSD1 Inhibitor - CAS 927019-63-4 - Calbiochem

489476
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      Replacement Information

      Tableau de caractéristiques principal

      Empirical FormulaCAS #
      C₁₅H₄₀Cl₄N₈ 927019-63-4

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      489476-10MG
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      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
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          Flacon en verre 10 mg
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          Description
          OverviewA bisguanidine polyamine analogue that exhibits noncompetitive and specific LSD1 inhibition, with 14.1% remaining LSD1 activity at 10 µM in vitro, and is shown to significantly increase methylation at the histone 3 lysine 4 chromatin mark (H3K4me1 and H3K4me2) dose-dependently from 0.25 µM to 10 µM, without affecting global H3K9me2 (which is not a LSD1 substrate) levels in HCT116 human colon carcinoma cells. This compound induces reexpression of several epigenetically silenced genes including SFRP1, SFRP4, SFRP5, and GATA5 more effectively when compared with siRNA treatment, particularly in the case of SFRP4 and SFRP5.
          Catalogue Number489476
          Brand Family Calbiochem®
          SynonymsLSD Inhibitor I, BHC110 Inhibitor I, Histone Lysine Demethylase Inhibitor III, KDM1 Inhibitor I
          References
          ReferencesSharma, SK., et al. 2010 J. Med. Chem. 53, 5197.
          Huang, Y., et al. 2007. Proc. Natl. Acad. Sci. 104, 8023.
          Bi, X., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3229.
          Product Information
          CAS number927019-63-4
          FormPale yellow to yellow solid
          Hill FormulaC₁₅H₄₀Cl₄N₈
          Chemical formulaC₁₅H₄₀Cl₄N₈
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          LSD1 Inhibitor - CAS 927019-63-4 - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          LSD1 Inhibitor - CAS 927019-63-4 - Calbiochem Certificats d'analyse

          TitreNuméro de lot
          489476

          Références bibliographiques

          Aperçu de la référence bibliographique
          Sharma, SK., et al. 2010 J. Med. Chem. 53, 5197.
          Huang, Y., et al. 2007. Proc. Natl. Acad. Sci. 104, 8023.
          Bi, X., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3229.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-July-2011 RFH
          SynonymsLSD Inhibitor I, BHC110 Inhibitor I, Histone Lysine Demethylase Inhibitor III, KDM1 Inhibitor I
          DescriptionA bisguanidine polyamine analogue that exhibits noncompetitive and specific LSD1 inhibition, with 14.1% remaining LSD1 activity at 10 µM in vitro, and is shown to significantly increase methylation at the histone 3 lysine 4 chromatin mark (H3K4me1 and H3K4me2) dose-dependently from 0.25 µM to 10 µM, without affecting global H3K9me2 (which is not a LSD1 substrate) levels in HCT116 human colon carcinoma cells. This compound induces reexpression of several epigenetically silenced genes including SFRP1, SFRP4, SFRP5, and GATA5 more effectively when compared with siRNA treatment, particularly in the case of SFRP4 and SFRP5.
          FormPale yellow to yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number927019-63-4
          Chemical formulaC₁₅H₄₀Cl₄N₈
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityH₂O (50 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSharma, SK., et al. 2010 J. Med. Chem. 53, 5197.
          Huang, Y., et al. 2007. Proc. Natl. Acad. Sci. 104, 8023.
          Bi, X., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3229.