505770 LSD1 Inhibitor VI, Cpd 2d - Calbiochem

505770
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical Formula
      C₄₇H₆₈N₁₂

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      5057700001
      Récupération des données relatives à la disponibilité...
      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
          Pour le restant : Nous vous tiendrons informé
          Nous vous tiendrons informé
          Contacter le Service Clients
          Contact Customer Service

          Flacon en verre 5 mg
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          Description
          OverviewA cell-permeable polyamine derivative that acts as an inhibitor of lysine-specific demethylase-1 (LSD1, KDM1) and increases levels of mono- and di-methylated histone H3K4, H3K9 proteins in acute myeloid leukemia (AML) cancer cells in a dose-dependent manner. Shown to cause significant growth inhibition in different AML cell lines (HL-60, KG1a, HNT-34, and ML-1 cells) at low micromolar concentrations (5 to 10 µM) over a period of 96 hours. Induces re-expression of cancer suppressing E-caherin gene and CDH-1 mRNA in tumor cells (˜10 µM). Also, displays anti-trypanosomal properties and inhibits trypanothione reductase activity (IC50 = 950 nM) in Trypanosoma brucei brucei.

          Please note that the molecular weight for this compound is batch-specific due to variable water content.
          Catalogue Number505770
          Brand Family Calbiochem®
          Synonyms1,15-bis{N5-[3,3-(diphenyl)propyl]-N1-biguanido}-4,12-diazapentadecane
          References
          ReferencesMurray-Stewart, T., et al. 2013, Amino Acids 44, in press.
          Bi, X. et al. 2006, Bioorg. Med. Chem. Lett. 16,3229.
          Product Information
          FormOff-white solid
          Hill FormulaC₄₇H₆₈N₁₂
          Chemical formulaC₄₇H₆₈N₁₂
          Hygroscopic Hygroscopic
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetLSD1
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          LSD1 Inhibitor VI, Cpd 2d - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Références bibliographiques

          Aperçu de la référence bibliographique
          Murray-Stewart, T., et al. 2013, Amino Acids 44, in press.
          Bi, X. et al. 2006, Bioorg. Med. Chem. Lett. 16,3229.

          Brochure

          Titre
          NPI Flyer- Epigenetics and Nuclear Function Feature
          New Products - Antibodies, Small Molecule, Inhibitors (MM)

          Informations techniques

          Titre
          White Paper: Further considerations of antibody validation and usage.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-September-2014 JSW
          Synonyms1,15-bis{N5-[3,3-(diphenyl)propyl]-N1-biguanido}-4,12-diazapentadecane
          DescriptionA cell-permeable polyamine derivative that acts as an inhibitor of lysine-specific demethylase-1 (LSD1, KDM1) and increases levels of mono- and di-methylated histone H3K4, H3K9 proteins in acute myeloid leukemia (AML) cancer cells in a dose-dependent manner. Shown to cause significant growth inhibition in different AML cell lines (HL-60, KG1a, HNT-34, and ML-1 cells) at low micromolar concentrations (5 to 10 µM) over a period of 96 hours. Induces re-expression of cancer suppressing E-caherin gene and CDH-1 mRNA in tumor cells (˜10 µM). Also, displays anti-trypanosomal properties and inhibits trypanothione reductase activity (IC50 = 950 nM) in Trypanosoma brucei brucei.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₄₇H₆₈N₁₂
          Purity≥98% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesMurray-Stewart, T., et al. 2013, Amino Acids 44, in press.
          Bi, X. et al. 2006, Bioorg. Med. Chem. Lett. 16,3229.