500501 iPSC Induction Enhancer II, OAC1 - CAS 300586-90-7 - Calbiochem

500501
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      Tableau de caractéristiques principal

      Empirical FormulaCAS #
      C₁₄H₁₁N₃O 300586-90-7

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      5005010001
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          Flacon en verre 25 mg
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          Description
          OverviewA cell-permeable pyrrolopyridinyl-benzamide compound that is reported to enhance the efficiency of 4F/4TF-induced iPSC generation from MEFs cultured in either feeder cell-containing ESC media or in feeder-/serum-free iSF1 media (1 µM OAC1 treatment starts 48 h after viral transduction). OCA1 is shown to increase cellular Oct4, Nanog, Sox2, and Tet1 mRNA levels via a yet unidentified mechanism, although OAC1 is reported not affect Oct4 promoter methylation, cellular Wnt signaling, or p53 and p21 mRNA levels. Six other iPSC reprogramming improving reagents, AM580, AzaC, BIX-01294 (Cat. No. 382190), Tranylcypromine (Cat. No. 616431), VPA (Cat. No. 676380), and Vitamin C (Cat. No. 1813), in comparison, do not exhibit Oct4 and Nanog promoters enhancing activity, while BIO (Cat. No. 361550) is demonstrated to be 3.8- and 6-fold less potent than OAC1, respectively, in inducing Oct4 and Nanog transcription.

          Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
          Catalogue Number500501
          Brand Family Calbiochem®
          SynonymsN-(1H-Pyrrolo[2,3-c]pyridin-5-yl)benzamide, Induced Pluripotent Stem Cells Induction Enhancer II, Oct4-Activating Compound 1
          References
          ReferencesLi, W., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 20853.
          Product Information
          CAS number300586-90-7
          FormOff-white solid
          Hill FormulaC₁₄H₁₁N₃O
          Chemical formulaC₁₄H₁₁N₃O
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥99% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          iPSC Induction Enhancer II, OAC1 - CAS 300586-90-7 - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Références bibliographiques

          Aperçu de la référence bibliographique
          Li, W., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 20853.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision07-September-2013 JSW
          SynonymsN-(1H-Pyrrolo[2,3-c]pyridin-5-yl)benzamide, Induced Pluripotent Stem Cells Induction Enhancer II, Oct4-Activating Compound 1
          DescriptionA cell-permeable pyrrolopyridinyl-benzamide compound that is reported to enhance the efficiency of 4F/4TF- (OSKM; Oct44, Sox2, Klf4, c-Myc) driven iPSC generation from MEFs cultured in either feeder cell-containing ESC media (induction efficiency 20 d post viral transduction = 0.43% vs. 0.186%, respectively, with or without 1 µM OAC1 treatment from d2 to d20) or in feeder-/serum-free iSF1 media (efficiency 10 d post viral transduction = 2.75% vs. 0.68%, respectively, with or without 1 µM OAC1 treatment from d2 to d10). OCA1 is shown to increase cellular Oct4, Nanog, Sox2, and Tet1 mRNA levels via a yet unidentified mechanism, although OAC1 is reported not to affect Oct4 promoter methylation, cellular Wnt signaling, or p53 and p21 mRNA levels. Six other iPSC reprogramming improving reagents, AM580, AzaC, BIX-01294 (Cat. No. 382190), Tranylcypromine (Cat. No. 616431), VPA (Cat. No. 676380), and Vitamin C (Cat. No. 1813), in comparison, do not exhibit Oct4 and Nanog promoters enhancing activity, while BIO (Cat. No. 361550) is demonstrated to be 3.8- and 6-fold less potent than OAC1, respectively, in inducing Oct4 and Nanog transcription (in human ESCs-based reporter assays).
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number300586-90-7
          Chemical formulaC₁₄H₁₁N₃O
          Structure formulaStructure formula
          Purity≥99% by HPLC
          SolubilityDMSO (100 mg/ml). Use only fresh DMSO for reconstitution.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesLi, W., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 20853.