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499610 (5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
66018-38-0C₁₉H₂₂O₇

Products

Catalogue NumberPackaging Qty/Pack
499610-1MG Glass bottle 1 mg
Description
OverviewA naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity (IC50 = 8 nM) in an ATP-competitive and irreversible manner, while inhibiting MEK1 (IC50 = 411 nM) and three other MAPKKKs (IC50 ≥268 nM against MEKK1, ASK1, and MEKK4) only at much higher concentrations. Shown to inhibit IL-1-induced/TAK1-mediated, but not H2O2-induced/TAK1-independent, JNK and p38 phosphorylation in 293 cells. (5Z)-Zeaenol, Curvularia sp. (Cat. No. 499609) may serve as a negative control.
Catalogue Number499610
Brand Family Calbiochem®
SynonymsTAK1 Inhibitor
References
ReferencesWindheim, M., et al. 2007. Biochem. J. 404, 179.
Choo, M.K., et al. 2006. Mol. Cancer Ther. 5, 2970.
Safwat, N., et al. 2005. Endocrinology 146, 4814.
Ninomiya-Tsuji, J., et al. 2003. J. Biol. Chem. 278, 18485.
Rawlins, P., et al. 1999. Int. J. Immunopharmacol. 21, 799.
Product Information
CAS number66018-38-0
FormWhite solid
Hill FormulaC₁₉H₂₂O₇
Chemical formulaC₁₉H₂₂O₇
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25-36/37/39

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
499610-1MG 04055977199277

Documentation

(5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

(5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem Certificates of Analysis

TitleLot Number
499610

References

Reference overview
Windheim, M., et al. 2007. Biochem. J. 404, 179.
Choo, M.K., et al. 2006. Mol. Cancer Ther. 5, 2970.
Safwat, N., et al. 2005. Endocrinology 146, 4814.
Ninomiya-Tsuji, J., et al. 2003. J. Biol. Chem. 278, 18485.
Rawlins, P., et al. 1999. Int. J. Immunopharmacol. 21, 799.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-December-2018 JSW
SynonymsTAK1 Inhibitor
DescriptionA naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity (IC50 = 8 nM) in an ATP-competitive and irreversible manner, while inhibiting MEK1 (IC50 = 411 nM) and three other MAPKKKs (IC50 ≥268 nM against MEKK1, ASK1, and MEKK4) only at much higher concentrations. Shown to inhibit IL-1-induced/TAK1-mediated, but not H2O2-induced/TAK1-independent, JNK and p38 phosphorylation in 293 cells. (5Z)-Zeaenol, Curvularia sp.(Cat. No. 499609) may serve as a negative control.
FormWhite solid
CAS number66018-38-0
Chemical formulaC₁₉H₂₂O₇
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesWindheim, M., et al. 2007. Biochem. J. 404, 179.
Choo, M.K., et al. 2006. Mol. Cancer Ther. 5, 2970.
Safwat, N., et al. 2005. Endocrinology 146, 4814.
Ninomiya-Tsuji, J., et al. 2003. J. Biol. Chem. 278, 18485.
Rawlins, P., et al. 1999. Int. J. Immunopharmacol. 21, 799.