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171258 AMPK Signaling Activator XV - CAS 844499-71-4 - Calbiochem

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Key Spec Table

CAS #Empirical Formula


Catalogue NumberPackaging Qty/Pack
171258-5MG Plastic ampoule 5 mg
OverviewA cell-permeable thienopyridone compound that acts as a direct, potent, selective, reversible, and allosteric activator of AMPK (EC50 = 0.8 µM, 1.9 µM and 2.2 µM in partially purified AMPK from rat liver, muscle and heart, respectively; 0.7 µM for AMPKα1,β1,γ1 isoform and 1.1 µM in HEK cells). Acts by inhibiting the dephosphorylation of AMPKT172. Does neither affect GPPase and FBPase activities at 100 µM, and a panel of 67-receptors and ion-channels at 10 µM nor alter the intracellular levels of ATP and AMP. Specifically stimulates hepatic AMPK in ob/ob mouse model (30 mg/kg, i.p.), improves insulin-sensitivity and regulates glucose and lipid metabolism. Shown to reduce mRNA expression levels of several gluconeogenic enzymes.
Catalogue Number171258
Brand Family Calbiochem®
Synonyms6,7-Dihydro-4-hydroxy-3-(2ʹ-hydroxy(1,1ʹ-biphenyl)-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile, A769662, 4-Hydroxy-3-(2ʹ-hydroxybiphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
ReferencesSanders, M.J., et al. 2007. J. Biol. Chem. 282, 32539.
Cool, B., et al. 2006. Cell Metab. 3, 403.
Product Information
CAS number844499-71-4
FormOff-white solid
Hill FormulaC₂₀H₁₂N₂O₃S
Chemical formulaC₂₀H₁₂N₂O₃S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsSoluble in DMSO (mg/ml), EtOH (mg/ml); aliquot and store at -20*C; stable for 6 months.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Global Trade Item Number
Catalogue Number GTIN
171258-5MG 04053252040863


AMPK Signaling Activator XV - CAS 844499-71-4 - Calbiochem SDS


Safety Data Sheet (SDS) 

AMPK Signaling Activator XV - CAS 844499-71-4 - Calbiochem Certificates of Analysis

TitleLot Number


Reference overview
Sanders, M.J., et al. 2007. J. Biol. Chem. 282, 32539.
Cool, B., et al. 2006. Cell Metab. 3, 403.