114825 Sigma-AldrichAdapalene - CAS 106685-40-9 - Calbiochem
A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα.
More>> A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα. Less<<Synonyms: Differin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271, CD271, RAR Agonist V, ADA
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Overview
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Key Spec Table
CAS # | Empirical Formula |
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106685-40-9 | C₂₈H₂₈O₃ |
Products
Catalogue Number | Packaging | Qty/Pack | |
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114825-25MG | 25 mg |
Description | |
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Overview | A cell-permeable naphthoic acid compound that exhibits selective affinity and agonistic potency toward RARβ and RARγ over RARα (Kd = 34, 130, and 1100 nM, respectively; AC50 = 2.3, 9.3, and 22 nM, respectively, in COS-7-based reporter assays) without appreciable affinity toward cytosolic retinoic acid binding proteins CRABP I/II (Kd >> 1 µM) or detectable activity toward RXRα (AC50 > 1 µM). The biological activity and pharmaceutical efficacy of ADA are generally shown to be superior to those of ATRA/Tretinoin (Cat. No. 554720) both in vitro and in vivo. |
Catalogue Number | 114825 |
Brand Family | Calbiochem® |
Synonyms | Differin, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, CD 271, CD271, RAR Agonist V, ADA |
Product Information | |
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CAS number | 106685-40-9 |
Form | White solid |
Hill Formula | C₂₈H₂₈O₃ |
Chemical formula | C₂₈H₂₈O₃ |
Structure formula Image | |
Quality Level | MQ100 |
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Biological Information | |
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Purity | ≥97% by HPLC |
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Packaged under inert gas | Packaged under inert gas |
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Specifications |
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Global Trade Item Number | |
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Catalogue Number | GTIN |
114825-25MG | 04055977208122 |
Documentation
Adapalene - CAS 106685-40-9 - Calbiochem SDS
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Adapalene - CAS 106685-40-9 - Calbiochem Certificates of Analysis
Title | Lot Number |
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114825 |
References
Reference overview |
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Irby, C.E., et al. 2008. J. Adolesc. Health 43, 421. Ocker, M., et al. 2003. Int. J. Cancer 107, 453. Kim, M.J., et al. 2000. J. Invest. Dermatol. 114, 349. Shroot, B., et al. 1997. J. Am. Acad. Dermatol. 36, S96. |
Brochure
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Undisputed Accuracy for Your Quantitative Results |
Technical Info
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Programming data for Spectrophotometer and Spectroquant Test Kits |