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119149 Adenosine A2A Receptor Antagonist I, ZM 241385 - CAS 139180-30-6 - Calbiochem

119149
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
139180-30-6C₁₆H₁₅N₇O₂

Products

Catalogue NumberPackaging Qty/Pack
119149-5MG Glass bottle 5 mg
Description
OverviewA highly potent, selective, and orally bioavailable non-xanthine adenosine A2A receptor antagonist (Ki = 800 pM for human adenosine A2AR stably expressed in HEK-293 cells). Does not exhibit any significant antagonistic activity in A1, A2B (Ki = 255 nM and 50 nM, respectively in human adenosine receptors stably expressed in CHO cells) or in A3R (Ki > 10 µM in human A3R stably expressed in HEK-293 cells). Shown to have a protective effect against beta-amyloid peptide toxicity.
Catalogue Number119149
Brand Family Calbiochem®
Synonyms4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino)ethyl)phenol, ZM-241385, ZM241385
References
ReferencesPoucher, S. M., et al. 1995. Brit. J. Pharmacol. 115, 1096.
Ongini, E. et al. 1999. Naunyn Schmiedebergs Arch Pharmacol. 359, 7.
Keddie, J. et al. 1996, Eur Journ Pharm. 301, 107.
Product Information
CAS number139180-30-6
FormWhite to beige powder
Hill FormulaC₁₆H₁₅N₇O₂
Chemical formulaC₁₆H₁₅N₇O₂
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary TargetA2A
Primary Target K<sub>i</sub>800 pM
Purity≥97.5% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Adenosine A2A Receptor Antagonist I, ZM 241385 - CAS 139180-30-6 - Calbiochem Certificates of Analysis

TitleLot Number
119149

References

Reference overview
Poucher, S. M., et al. 1995. Brit. J. Pharmacol. 115, 1096.
Ongini, E. et al. 1999. Naunyn Schmiedebergs Arch Pharmacol. 359, 7.
Keddie, J. et al. 1996, Eur Journ Pharm. 301, 107.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-December-2019 JSW
Synonyms4-(2-((7-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino)ethyl)phenol, ZM-241385, ZM241385
DescriptionA highly potent, selective, and orally bioavailable non-xanthine adenosine A2A receptor antagonist (Ki = 800 pM for human adenosine A2AR stably expressed in HEK-293 cells). Does not exhibit any significant antagonistic activity in A1, A2B (Ki = 255 nM and 50 nM, respectively in human adenosine receptors stably expressed in CHO cells) or in A3R (Ki > 10 µM in human A3R stably expressed in HEK-293 cells). Shown to have a protective effect against beta-amyloid peptide toxicity.
FormWhite to beige powder
Intert gas (Yes/No) Packaged under inert gas
CAS number139180-30-6
Chemical formulaC₁₆H₁₅N₇O₂
Purity≥97.5% by HPLC
SolubilityDMSO (≥15 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesPoucher, S. M., et al. 1995. Brit. J. Pharmacol. 115, 1096.
Ongini, E. et al. 1999. Naunyn Schmiedebergs Arch Pharmacol. 359, 7.
Keddie, J. et al. 1996, Eur Journ Pharm. 301, 107.