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AB19011 Anti-Tenascin Antibody

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AB19011
50 µg  
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Overview

Replacement Information

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB19011
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Tenascin Antibody
Alternate Names
  • Tenascin C
Background InformationTenascin is known to play an active role in development of central nervous system and mesenchymal-derived organs, exist in the vasculature of tumors in adults, and function in cell adhesion.
References
Product Information
FormatAffinity Purified
HS Code3002 15 90
PresentationAffinity purified using immobilized human tenascin; presented as a liquid in PBS containing no preservatives.
Quality LevelMQ100
Applications
ApplicationThis Anti-Tenascin Antibody is validated for use in WB, IH(P) for the detection of Tenascin.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesWestern blot: 0.5 - 1.0 μg/mL; recognizes 250-350 kDa polypeptides in reduced samples.
Immunohistochemistry: 10 to 20 μg/mL in paraffin embedded tissues

Optimal working dilutions must be determined by end user.
Biological Information
ImmunogenPurified human tenascin from glioma culture supernatant.
HostRabbit
SpecificityReacts strongly with tenascin from human and mouse in both Western blotting and immunohistochemistry. While it has not been tested, it should also react strongly in these applications with tenascin from all mammalian species.
Species Reactivity
  • Human
  • Mouse
Species Reactivity NoteReactivity with other species has not been confirmed, but likely to react with all mammalian species.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • TNC
  • Hexabrachion
  • HXB
  • GMEM
  • TN
  • Neuronectin
  • Tenascin-C
  • MGC167029
  • JI
  • TN-C
  • Cytotactin
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P24821 # Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.
SIZE: 2201 amino acids; 240866 Da
SUBUNIT: Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4.
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
PTM: N-glycosylated (By similarity).
SIMILARITY: SwissProt: P24821 ## Belongs to the tenascin family. & Contains 15 EGF-like domains. & Contains 1 fibrinogen C-terminal domain. & Contains 15 fibronectin type-III domains.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20°C for up to 12 months from date of receipt. Aliquot to avoid repeated freeze/thaw cycles.
Packaging Information
Material Size50 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
AB19011 04053252328237

Documentation

Anti-Tenascin Antibody SDS

Title

Safety Data Sheet (SDS) 

Anti-Tenascin Antibody Certificates of Analysis

TitleLot Number
RABBIT ANTI-HUMAN TENASCIN POLYCLONAL ANTIBODY - 2121731 2121731
RABBIT ANTI-HUMAN TENASCIN - 3016017 3016017
RABBIT ANTI-HUMAN TENASCIN - 3201058 3201058
RABBIT ANTI-HUMAN TENASCIN - 3455168 3455168
RABBIT ANTI-HUMAN TENASCIN - 3824858 3824858
RABBIT ANTI-HUMAN TENASCIN - 3891811 3891811
RABBIT ANTI-HUMAN TENASCIN - 3991492 3991492
RABBIT ANTI-HUMAN TENASCIN -2701546 2701546
RABBIT ANTI-HUMAN TENASCIN -2709142 2709142
RABBIT ANTI-HUMAN TENASCIN -2713611 2713611

References

Reference overviewApplicationSpeciesPub Med ID
Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival.
Phua, YL; Chu, JY; Marrone, AK; Bodnar, AJ; Sims-Lucas, S; Ho, J
Physiological reports  3  2015

Show Abstract
26438731 26438731
Ablation of the renal stroma defines its critical role in nephron progenitor and vasculature patterning.
Hum, S; Rymer, C; Schaefer, C; Bushnell, D; Sims-Lucas, S
PloS one  9  e88400  2014

Show Abstract
24505489 24505489
The effects of tenascin C knockdown on trabecular meshwork outflow resistance.
Keller, KE; Vranka, JA; Haddadin, RI; Kang, MH; Oh, DJ; Rhee, DJ; Yang, YF; Sun, YY; Kelley, MJ; Acott, TS
Investigative ophthalmology & visual science  54  5613-23  2013

Show Abstract
Immunohistochemistry23882691 23882691
Loss of caveolin-1 from bronchial epithelial cells and monocytes in human subjects with asthma.
Bains, SN; Tourkina, E; Atkinson, C; Joseph, K; Tholanikunnel, B; Chu, HW; Riemer, EC; Martin, R; Hoffman, S
Allergy  67  1601-4  2012

Show Abstract
23004679 23004679
Neuronal replacement in the injured olfactory bulb.
Liu, H; Guthrie, KM
Experimental neurology  228  270-82  2011

Show Abstract
ImmunohistochemistryMouse21310147 21310147
Antifibrotic properties of caveolin-1 scaffolding domain in vitro and in vivo.
Tourkina, E; Richard, M; Gööz, P; Bonner, M; Pannu, J; Harley, R; Bernatchez, PN; Sessa, WC; Silver, RM; Hoffman, S
American journal of physiology. Lung cellular and molecular physiology  294  L843-61  2008

Show Abstract
18203815 18203815