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MAB5550 Anti-TorsinA Antibody

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100 µL  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RIP, WB, ICCMAscitesMonoclonal Antibody
Catalogue NumberMAB5550
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-TorsinA Antibody
Background InformationTorsinA can regulate the cellular trafficking of the dopamine transporter, as well as other polytopic membrane-bound proteins, including G protein-coupled receptors, transporters, and ion channels. TorsinA is found in the dopamine neurons that are lost in PD, and is a component of Lewy bodies. in addition, a genetic defect in TorsinA underlies Torsion dystonia, a disease characterized by painful muscle contractions that result in uncontrollable distortions.
Product Information
  • Positive Control: Human brain lysate, NGF treated PC12 cells.
PresentationLiquid. Contaings no preservative
Quality LevelMQ100
ApplicationThis Anti-TorsinA Antibody is validated for use in IP, WB, IC for the detection of TorsinA.
Key Applications
  • Immunoprecipitation
  • Western Blotting
  • Immunocytochemistry
Biological Information
ImmunogenMaltose binding protein fusion protein from human torsinA.
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene is a member of the AAA family of adenosine triphosphatases (ATPases), is related to the Clp protease/heat shock family and is expressed prominently in the substantia nigra pars compacta. Mutations in this gene result in the autosomal dominant disorder, torsion dystonia 1.
Gene Symbol
  • TOR1A
  • DQ1
  • DYT1
  • TOR1B
  • DQ2
Purification MethodAscites
UniProt Number
UniProt SummaryFUNCTION: SwissProt: O14656 # May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins.
SIZE: 332 amino acids; 37809 Da
SUBUNIT: Interacts with TOR1AIP1 and TOR1AIP2.
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. Nucleus membrane. Note=Mainly located in the lumen of the endoplasmic reticulum. Also found associated with the nuclear envelope. The Glu-303 del variant is lumenally-oriented in discrete large spheroid intracellular structures rather than in the endoplasmic reticulum.
TISSUE SPECIFICITY: Widely expressed. Highest levels in kidney and liver. Not detected in spleen. In the brain, high levels found in the dopaminergic neurons of the substantia nigra pars compacta, as well as in the neocortex, hippocampus and cerebellum. Also high expression in the spinal cord.
DISEASE: SwissProt: O14656 # Defects in TOR1A are the cause of torsion dystonia 1 (DYT1) [MIM:128100]; also known as primary or idiopathic dystonia. This autosomal dominant disorder is the most common and severe type of dystonia manifesting itself as sustained muscle contractions inducing twisting and repetitive movements and/or abnormal posture. Symptoms usually begin in the arms or legs at a mean age of 12 years and progress to other body parts within 5 years.
SIMILARITY: SwissProt: O14656 ## Belongs to the clpA/clpB family. Torsin subfamily.
Molecular Weight37kDa
Physicochemical Information
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Global Trade Item Number
Catalogue Number GTIN
MAB5550 04053252359651


Anti-TorsinA Antibody SDS


Safety Data Sheet (SDS) 

Anti-TorsinA Antibody Certificates of Analysis

TitleLot Number
MOUSE ANTI-TORSINA - 3385746 3385746
MOUSE ANTI-TORSINA - 3423517 3423517
MOUSE ANTI-TORSINA - 3450036 3450036
MOUSE ANTI-TORSINA - 3506479 3506479
MOUSE ANTI-TORSINA - 3596196 3596196
MOUSE ANTI-TORSINA - 3660332 3660332
MOUSE ANTI-TORSINA - 3836462 3836462
MOUSE ANTI-TORSINA - 3888800 3888800
MOUSE ANTI-TORSINA - 3893417 3893417


Reference overviewPub Med ID
Developmental patterns of torsinA and torsinB expression
Vasudevan, Anju, et al
Brain Res, 1073-1074:139-45 (2006)  2006

16458269 16458269
The early onset dystonia protein torsinA interacs with kinesin light chain 1
Kamm, C. et al.
J. Biol. Chem., 279(19):19882-19892 (2004)  2004

14970196 14970196
Perinuclear biogenesis of mutant torsin-A inclusions in cultured cells infected with tetracycline-regulated herpes simplex virus type 1 amplicon vectors.
Bragg, D C, et al.
Neuroscience, 125: 651-61 (2004)  2004

Show Abstract
15099679 15099679
TorsinB--perinuclear location and association with torsinA.
Hewett, Jeffrey W, et al.
J. Neurochem., 89: 1186-94 (2004)  2004

Show Abstract
15147511 15147511
TorsinA in PC12 cells: localization in the endoplasmic reticulum and response to stress.
Hewett, Jeffrey, et al.
J. Neurosci. Res., 72: 158-68 (2003)  2003

Show Abstract
12671990 12671990