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218753 Caspase-5 Inhibitor I

218753
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₃₇H₄₂FN₇O₁₀

Products

Catalogue NumberPackaging Qty/Pack
218753-1MG Plastic ampoule 1 mg
Description
OverviewA potent, cell-permeable, and irreversible inhibitor of caspase-5. Strongly inhibits caspase-1. Also inhibits caspase-4 and caspase-8.
Catalogue Number218753
Brand Family Calbiochem®
SynonymsZ-WE(OMe)HD(OMe)-FMK
References
ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Rano, T., et al. 1997. Chem. Biol. 4, 149.
Product Information
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₃₇H₄₂FN₇O₁₀
Chemical formulaC₃₇H₄₂FN₇O₁₀
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary Targetcaspase-1, caspase-4, caspase-5, caspase-8
Puritysingle spot by TLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Trp-Glu(OMe)-His-Asp(OMe)-CH₂F*
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 4 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Caspase-5 Inhibitor I SDS

Title

Safety Data Sheet (SDS) 

Caspase-5 Inhibitor I Certificates of Analysis

TitleLot Number
218753

References

Reference overview
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Rano, T., et al. 1997. Chem. Biol. 4, 149.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision02-June-2008 JSW
SynonymsZ-WE(OMe)HD(OMe)-FMK
DescriptionA potent, cell-permeable and irreversible inhibitor of caspase-5 (ICErel-III, TY), as well as caspase-1 and caspase-4.
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Chemical formulaC₃₇H₄₂FN₇O₁₀
Peptide SequenceZ-Trp-Glu(OMe)-His-Asp(OMe)-CH₂F*
Puritysingle spot by TLC
SolubilityDMSO (5 mg/ml)
Storage -20°C
Protect from moisture
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 4 months at 4°C.
Toxicity Standard Handling
ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Rano, T., et al. 1997. Chem. Biol. 4, 149.