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238803 Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem

The Cdk2 Inhibitor III, also referenced under CAS 199986-75-9, controls the biological activity of Cdk2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine, CVT-313

Primary Target: Cdk2/A, Cdk2/E
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238803
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
199986-75-9C₂₀H₂₈N₆O₃

Products

Catalogue NumberPackaging Qty/Pack
238803-1MG Plastic ampoule 1 mg
238803-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC50 = 0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1). Inhibits other kinases only at much higher concentrations (IC50 > 1.25 mM for MAPK, PKA, and PKC). Shown to induce tumor cells growth arrest (IC50 = ~1.25-20 µM) in vitro and prevent neointima formation in vivo.
Catalogue Number238803
Brand Family Calbiochem®
Synonyms2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine, CVT-313
References
ReferencesBhattacharjee, R.N., et al. 2001. Mol. Cell. Biol. 21, 5417.
Brooks, E.E., et al. 1997. J. Biol. Chem. 272, 29207.
Product Information
CAS number199986-75-9
ATP CompetitiveY
DeclarationSold under license of U.S. Patents 6,617,331 and 6,803,371.
FormWhite to off-white solid
Hill FormulaC₂₀H₂₈N₆O₃
Chemical formulaC₂₀H₂₈N₆O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCdk2/A, Cdk2/E
Primary Target IC<sub>50</sub>0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
238803-1MG 04055977216608
238803-5MG 04055977216615

Documentation

Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cdk2 Inhibitor III - CAS 199986-75-9 - Calbiochem Certificates of Analysis

TitleLot Number
238803

References

Reference overview
Bhattacharjee, R.N., et al. 2001. Mol. Cell. Biol. 21, 5417.
Brooks, E.E., et al. 1997. J. Biol. Chem. 272, 29207.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-October-2020 JSW
Synonyms2(bis-(Hydroxyethyl)amino)-6-(4-methoxybenzylamino)-9-isopropyl-purine, CVT-313
DescriptionA cell-permeable purine analog that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Cdk2 (IC50 = 0.5 µM for Cdk2/A and Cdk2/E; 4.2 µM for Cdk1/B; 215 µM for Cdk4/D1). Inhibits other kinases only at much higher concentrations (IC50 > 1.25 mM for MAPK, PKA, and PKC). Shown to induce tumor cells growth arrest (IC50 ~1.25-20 µM) in vitro and prevent neointima formation in vivo.
FormWhite to off-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number199986-75-9
Chemical formulaC₂₀H₂₈N₆O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesBhattacharjee, R.N., et al. 2001. Mol. Cell. Biol. 21, 5417.
Brooks, E.E., et al. 1997. J. Biol. Chem. 272, 29207.