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344597 FTY720

344597
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₉H₃₃NO₂ • HCl

Products

Catalogue NumberPackaging Qty/Pack
344597-10MG Glass bottle 10 mg
Description
Overview

A cell-permeable aminopropanediol immunosuppressive agent that displays lymphocyte sequestration properties. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPγS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
Catalogue Number344597
Brand Family Calbiochem®
Synonyms2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol, HCl
References
ReferencesBrinkmann, V and Lynch, K. R., 2002. Curr. Opin. Immunol. 14, 569.
Brinkmann, V., et al. 2002. J. Biol. Chem. 277, 21453.
Mandala, S., et al. 2002. Science 296, 346.
Chiba, K., et al. 1998. J. Immunol. 160, 5037.
Adachi, K., et al. 1995. Bioorg. Med. Chem. Lett. 5, 583.
Product Information
CAS number162359-56-0
FormSolid
Hill FormulaC₁₉H₃₃NO₂ • HCl
Chemical formulaC₁₉H₃₃NO₂ • HCl
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

FTY720 Certificates of Analysis

TitleLot Number
344597

References

Reference overview
Brinkmann, V and Lynch, K. R., 2002. Curr. Opin. Immunol. 14, 569.
Brinkmann, V., et al. 2002. J. Biol. Chem. 277, 21453.
Mandala, S., et al. 2002. Science 296, 346.
Chiba, K., et al. 1998. J. Immunol. 160, 5037.
Adachi, K., et al. 1995. Bioorg. Med. Chem. Lett. 5, 583.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-June-2008 RFH
Synonyms2-Amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol, HCl
DescriptionA cell-permeable aminopropanediol immunosuppressive agent that displays lymphocyte sequestration properties. Reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPγS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
FormSolid
Intert gas (Yes/No) Packaged under inert gas
CAS number162359-56-0
Chemical formulaC₁₉H₃₃NO₂ • HCl
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (20 mg/ml) or Ethanol (20 mg/ml)
Storage -20°C
Hygroscopic
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBrinkmann, V and Lynch, K. R., 2002. Curr. Opin. Immunol. 14, 569.
Brinkmann, V., et al. 2002. J. Biol. Chem. 277, 21453.
Mandala, S., et al. 2002. Science 296, 346.
Chiba, K., et al. 1998. J. Immunol. 160, 5037.
Adachi, K., et al. 1995. Bioorg. Med. Chem. Lett. 5, 583.