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197334 InSolution™ Bcl-2 Inhibitor VI, ABT-737 - Calbiochem

197334
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₄₂H₄₅ClN₆O₅S₂

Products

Catalogue NumberPackaging Qty/Pack
197334-5MG Glass bottle 5 mg
Description
Catalogue Number197334
Brand Family Calbiochem®
Synonyms4-(4-((4ʹ-Chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-N-((4-(((1R)-3-(dimethylamino)-1-((phenylsulfanyl)methyl)propyl)amino)-3-nitrophenyl)sulfonyl)benzamide, (R)-4-(4-((4ʹ-Chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-N-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrophenylsulfonyl)benzamide
References
ReferencesBardwell, P.D., et al. 2009. J. Immunol. 182, 7482.
Oltersdorf, T., et al. 2005. Nature 435, 677.
Product Information
FormLiquid
FormulationA 25 mM (5 mg/246 µL) solution of Bcl-2 Inhibitor VI, ABT-737 (Cat. No. 197333) in DMSO.
Hill FormulaC₄₂H₄₅ClN₆O₅S₂
Chemical formulaC₄₂H₄₅ClN₆O₅S₂
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetBcl-2 family members
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C. For longer term storage of aliquots, store at -70°C. Use only fresh DMSO for further serial dilutions.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

InSolution™ Bcl-2 Inhibitor VI, ABT-737 - Calbiochem Certificates of Analysis

TitleLot Number
197334

References

Reference overview
Bardwell, P.D., et al. 2009. J. Immunol. 182, 7482.
Oltersdorf, T., et al. 2005. Nature 435, 677.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-March-2014 JSW
Synonyms4-(4-((4ʹ-Chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-N-((4-(((1R)-3-(dimethylamino)-1-((phenylsulfanyl)methyl)propyl)amino)-3-nitrophenyl)sulfonyl)benzamide, (R)-4-(4-((4ʹ-Chlorobiphenyl-2-yl)methyl)piperazin-1-yl)-N-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrophenylsulfonyl)benzamide
DescriptionA cell-permeable nitrophenylsulfonylbenzamide compound that is shown to bind anti-apoptotic Bcl-2 family members Bcl-2, Bcl-XL, and Bcl-w with high affinity (Ki ≤1 nM) and serves as a nonpeptidyl alternative to Bad-derived BH3 peptide (Cat. No. 197220) in preventing the binding and inhibition of the pro- apoptotic by the anti-apoptotic Bcl-2 family proteins. ABT-737 is demonstrated to fully reverse the blockage of Myr-Bid-induced cytochrome c release by Bcl-2 in mitochondria preparations from Bcl-2 overexpressing FL5.12 cells and effectively inhibit the growth of numerous cancer cells both in cultures in vitro (IC50 ≤100 nM against H146 and H1963) and in vivo (complete regression of H146 and H1963 in xenograft mice at 100 mg/kg/day, i.p.). Application of ABT-737 is also demonstrated to significantly reduce the disease severity in several murine models of autoimmunity.
FormLiquid
FormulationA 25 mM (5 mg/246 µL) solution of Bcl-2 Inhibitor VI, ABT-737 (Cat. No. 197333) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₄₂H₄₅ClN₆O₅S₂
Structure formulaStructure formula
Purity≥97% by HPLC
Storage ≤ -70°C
Hygroscopic
Protect from light
Avoid freeze/thaw
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C. For longer term storage of aliquots, store at -70°C. Use only fresh DMSO for further serial dilutions.
Toxicity Standard Handling
ReferencesBardwell, P.D., et al. 2009. J. Immunol. 182, 7482.
Oltersdorf, T., et al. 2005. Nature 435, 677.