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A2478

APHA Compound 8

Name: APHA Compound 8
Brand: SIGMA

solid, ≥98% (HPLC)

Synonym(s):

3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₆N₂O₃

CAS Number:

676599-90-9

Molecular Weight:

284.31

MDL number:

MFCD29074969

UNSPSC Code:

12352202

PubChem Substance ID:

329770785

NACRES:

NA.77

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Properties

Product Name

APHA Compound 8, ≥98% (HPLC), solid

Quality Segment

100

assay

≥98% (HPLC)

form

solid

solubility

DMSO: >10 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

Cn1cc(cc1\C=C\C(=O)NO)C(=O)Cc2ccccc2

InChI

1S/C16H16N2O3/c1-18-11-13(10-14(18)7-8-16(20)17-21)15(19)9-12-5-3-2-4-6-12/h2-8,10-11,21H,9H2,1H3,(H,17,20)/b8-7+

InChI key

UFQOXIMRSMFQRI-BQYQJAHWSA-N

Description

Biochem/physiol Actions

HDAC (histone deacetylase) inhibitor.

One of a class of aroyl pyrrole hydroxy amide (APHA) compounds showing histone deacetylase (HDAC) inhibition, Compound 8 is the most potent and HDAC class I-selective.

pictograms

GHS05,GHS07

signalword

Danger

hcodes

H302,H317,H318

pcodes

P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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