O3139
Oxamflatin
≥98% (HPLC), solid
Synonym(s):
(2E)-5-[3-(Phenylsulfonylamino)phenyl]-pent-2-en-4-ynohydroxamic acid
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About This Item
Empirical Formula (Hill Notation):
C17H14N2O4S
CAS Number:
Molecular Weight:
342.37
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352203
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Quality Segment
assay
≥98% (HPLC)
form
solid
solubility
DMSO: soluble 13 mg/mL
storage temp.
2-8°C
SMILES string
ONC(=O)\C=C\C#Cc1cccc(NS(=O)(=O)c2ccccc2)c1
InChI
1S/C17H14N2O4S/c20-17(18-21)12-5-4-7-14-8-6-9-15(13-14)19-24(22,23)16-10-2-1-3-11-16/h1-3,5-6,8-13,19,21H,(H,18,20)/b12-5+
InChI key
QRPSQQUYPMFERG-LFYBBSHMSA-N
Application
Oxamflatin has been used as a histone deacetylase (HDAC) inhibitor:
- to study its effect on specificity protein 1 (Sp1) transcription and transactivation activity and CD1d mRNA expression in various tumor cells
- to study its inhibitory effect on long transcript- survival motor neuron gene 2 (SMN2) silencing mediated by DNA methylation
- to study its effect on somatic embryogenesis in Coffea arabica thorough a miniaturized and automated screening system
- to study its stand-alone effect on cytarabine-sensitive and resistant cells.
Biochem/physiol Actions
Histone deacetylase inhibitor; anti-cancer agent.
Oxamflatin is an aromatic sulfonamide derivative with a hydroxamic acid group. It stimulates the expression of the transcription factor, JunD, and fibronectin. In addition, oxamflatin also aids in the morphological reversion of various NIH3T3-derived transformed cell lines. It inhibits the proliferation of various mouse and human tumor cell lines in vitro.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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