K0133
Kaempferol
≥90% (HPLC), powder
동의어(들):
3,4′,5,7-Tetrahydroxyflavone, 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one, Robigenin
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C15H10O6
CAS 번호:
Molecular Weight:
286.24
UNSPSC Code:
12191503
NACRES:
NA.25
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
304401
biological source
synthetic
Quality Segment
assay
≥90% (HPLC)
form
powder
storage condition
protect from light
color
yellow
mp
277 °C
solubility
ethanol: 20 mg/mL, DMSO: 50 mg/mL
storage temp.
room temp
SMILES string
Oc1ccc(cc1)C2=C(O)C(=O)c3c(O)cc(O)cc3O2
InChI
1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
InChI key
IYRMWMYZSQPJKC-UHFFFAOYSA-N
Gene Information
human ... CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), CYP2C9(1559), GSK3A(2931)
mouse ... Hexa(15211)
General description
Kaempferol is a natural dietary flavonoid and a polyphenol antioxidant found in various fruits and vegetables. Kaempferol is present in plants in a different glycosidic form such as astragalin by binding with different sugars.
Application
Chromogenic reagent for antimony in the low ppm range and for gallium and indium in the sub-ppm range.
Kaempferol (KAE) has been used:
- to check its potential effect as an antioxidant and neuroprotective agent against rotenone-induced Parkinson′s disease (PD) model in SH-S5Y5 cells
- to test its anti-inflammatory effect on lipopolysaccharide (LPS)-induced inflammatory injury in human aortic endothelial cells (HAECs)
- to study its apoptosis sensitizing effect on non-small cell lung cancer (NSCLC) cells by inhibiting nuclear factor erythroid 2-related factor 2 (Nrf2)
Biochem/physiol Actions
Potent inhibitor of osteoclastic bone resorption. The effect is believed to be attributable to both the antioxidant and estrogenic activities of kaempferol.
The diphenylpropane component of Kaempferol contributes to its hydrophobic properties. It has shown to revert the transformed phenotype of phorbol ester-treated mouse fibroblasts or v-H-ras-transformed NIH 3T3 cells. Kaempferol induces significant nuclear DNA degradation concurrent with lipid peroxidation. It also inhibits topoisomerase I catalyzed DNA religation. Kaempferol may also inhibit the activity of fatty acid synthase.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
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signalword
Warning
hcodes
저장 등급
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Classifications
Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2