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Merck

106425

N-Acetyl-L-cysteine

Mucolytic agent and thiol-based antioxidant that has a protective effect against oxygen free radicals in early septic shock.

Synonym(s):

N-Acetyl-L-cysteine, LNAC

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About This Item

Empirical Formula (Hill Notation):
C5H9NO3S
CAS Number:
616-91-1
Molecular Weight:
163.19
UNSPSC Code:
12352209
NACRES:
NA.25
MDL number:
MFCD00004880

Product Name

N-Acetyl-L-cysteine, Mucolytic agent and thiol-based antioxidant that has a protective effect against oxygen free radicals in early septic shock.

SMILES string

SCC(NC(=O)C)C(=O)O

InChI

1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)

InChI key

PWKSKIMOESPYIA-UHFFFAOYSA-N

description

Merck USA index - 14, 88

assay

≥98% (titration)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

water: 50 mg/mL

anion traces

chloride (Cl-): ≤0.04%
sulfate (SO42-): ≤0.03%

cation traces

Fe: ≤20 ppm

shipped in

ambient

storage temp.

15-25°C

Quality Level

200

Related Categories

Other Notes

Ortolani, O., et al. 2000. Am. J. Respir. Crit. Care Med. 161, 1907.
Tsai, J.C., et al. 1996. J. Biol. Chem. 271, 3667.
Ferrari, G., et al. 1995. J. Neurosci.15, 2857.
Weinander, R., et al. 1994. J. Biol. Chem.269, 71.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 month at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Application


  • Chlorpyrifos-induced suppression of the antioxidative defense system leads to cytotoxicity and genotoxicity in macrophages.: The study highlights the protective role of N-acetyl-L-cysteine against chlorpyrifos-induced oxidative damage in macrophages, emphasizing its importance in mitigating pesticide toxicity (Lu et al., 2024).

  • N-Acetyl-L-Cysteine Attenuates Titanium Dioxide Nanoparticle (TiO2 NP)-Induced Autophagy in Male Germ Cells.: This research explores how N-acetyl-L-cysteine can mitigate the autophagic effects induced by titanium dioxide nanoparticles in male germ cells, suggesting its use in reproductive health (Shin et al., 2024).


Disclaimer

Toxicity: Standard Handling (A)

General description

A mucolytic agent and thio-based antioxidant. Increases the cellular pool of free-radical scavengers. Inhibits HIV replication. Prevents apoptotic death of neuronal cells. Antidote for acetaminophen poisoning. May serve as a substrate for microsomal glutathione transferase. Induces apoptosis in human and rat smooth muscle cells.
Mucolytic agent and thiol-based antioxidant that has a protective effect against oxygen free radicals in early septic shock. Increases cellular pools of free-radical scavengers. Inhibitor of HIV replication. May serve as a substrate for microsomal glutathione transferase. Induces apoptosis in human and rat smooth muscle cells.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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