- Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells.
Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells.
The Biochemical journal (2017-07-12)
Robin Willows, Matthew J Sanders, Bing Xiao, Bhakti R Patel, Stephen R Martin, Jon Read, Jon R Wilson, Julia Hubbard, Steven J Gamblin, David Carling
PMID28694351
ABSTRACT
AMP-activated protein kinase (AMPK) plays a major role in regulating metabolism and has attracted significant attention as a therapeutic target for treating metabolic disorders. AMPK activity is stimulated more than 100-fold by phosphorylation of threonine 172 (Thr
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