341280
Factor I, Human
Factor I, Human, is a glycoprotein composed of two non-identical disulfide-bonded subunits of 50 and 38 kDa. A serine protease that requires protein cofactor in order to effect substrate cleavage.
Sinónimos:
C3b/C4b Inactivator
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NACRES:
NA.25
UNSPSC Code:
12352202
Form:
liquid
Assay:
≥95% (SDS-PAGE)
Servicio técnico
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Permítanos ayudarleQuality Segment
assay
≥95% (SDS-PAGE)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles
impurities
IgG, IgA, IgM, Factor H, Factor B, Factor P, C3, C4, or albumin, trace
shipped in
wet ice
storage temp.
−70°C
General description
Native factor I from human serum. Glycoprotein composed of two non-identical disulfide-bonded subunits of M.W. of 50 kDa (α) and 38 kDa (β). Present in normal human serum at about 34 µg/ml. A serine protease that requires protein cofactor in order to effect substrate cleavage. Thus, either Factor H or Factor I mediates cleavage of C3b. C4-binding protein or complement receptor CR1 can function as the cofactor required for Factor I-mediated cleavage of C4b.
Packaging
Please refer to vial label for lot-specific concentration.
Physical form
In PBS, pH 7.2.
Preparation Note
Following initial thaw, aliquot and freeze (-70°C).
Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Other Notes
Solol-Celigny, P., et al. 1982. Clin. Exp. Immunol. 47, 197.
Pangburn, M.K., et al. 1977. J. Exp. Med. 146, 257.
Pangburn, M.K., et al. 1977. J. Exp. Med. 146, 257.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Toxicity: Standard Handling (A)
Clase de almacenamiento
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
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