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ABT22

Anti-Endophilin-A1 Antibody

Name: Anti-Endophilin-A1 Antibody
Brand: MM

from rabbit, purified by affinity chromatography

Sinónimos:

SH3-domain GRB2-like 2, bA335L15.1 (SH3-domain GRB2-like 2), Endophilin A1 BAR domain, SH3 domain protein 2A, Endophilin-1, SH3 domain-containing GRB2-like protein 2

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UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

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Propiedades

biological source

rabbit

Quality Segment

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, rat

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NP_062408

UniProt accession no.

Q62420

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Sh3Gl2(20404)

Descripción

General description

A member of the Endophilin family, Endophilin A1 is a protein containing SH3 domains, and has been implicated in the trafficking of clathrin-mediated synaptic vesicle endocytosis within the membrane. It was originally characterized as a presynaptically enriched protein that binds to endocytic proteins polyphosphoinositide synaptojanin and dynamin. Endophilin A1 has been implicated in endocytic vesicle budding when its function in cell-free systems and in living synapses has been disturbed. Along with the SH3 domain, Endophilin A1 contains a BAR domain in the N-terminal region, that has been found to induce and bind membrane curvature. This protein’s expression is localized to the brain, most specifically in the frontal cortex. Markedly high expression is observed in fetal cerebellum.

~ 42 kDa

Immunogen

KLH-conjugated linear peptide corresponding to mouse Endophilin-A1.

Application

This Anti-Endophilin-A1 Antibody is validated for use in WB for the detection of Endophilin-A1.

Western Blot Analysis: 1:500 dilution from a previous lot detected Endophilin-A1 in 10 µg of rat brain and mouse brain membrane tissue lysates.

Biochem/physiol Actions

Human (94% sequence homology).

The antibody recognizes Endophilin-A1.

Analysis Note

Evaluated by Western Blot in mouse brain tissue lysate.

Western Blot Analysis: 1:500 dilution of this antibody detected Endophilin-A1 in 10 µg of mouse brain tissue lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Clase de almacenamiento

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c