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116850 Adenylyl Cyclase Type V Inhibitor, NKY80 - CAS 299442-43-6 - Calbiochem

The Adenylyl Cyclase Type V Inhibitor, NKY80, also referenced under CAS 299442-43-6, controls the biological activity of Adenylyl Cyclase Type V. This small molecule/inhibitor is primarily used for Cell Signaling applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Amino-7-(furanyl)-7,8-dihydro-5(6H)-quinazolinone

Primary Target: Adenylate cyclase (AC) type V isoform
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116850
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
299442-43-6C₁₂H₁₁N₃O₂

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      		 Plastic ampoule 5 mg
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      Description
      OverviewA cell-permeable quinazolinone containing a non-nucleoside compound that acts as a potent, selective inhibitor of adenylyl cyclase (AC) type V isoform (IC50 = 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively) in the presence of Gsα GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Regulates the AC catalytic activity in heart and lung tissues.
      Catalogue Number116850
      Brand Family Calbiochem®
      Synonyms2-Amino-7-(furanyl)-7,8-dihydro-5(6H)-quinazolinone
      References
      ReferencesOnda, T., et al. 2001. J. Biol. Chem. 276, 47785.
      Product Information
      CAS number299442-43-6
      ATP CompetitiveN
      FormPale orange solid
      Hill FormulaC₁₂H₁₁N₃O₂
      Chemical formulaC₁₂H₁₁N₃O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAdenylate cyclase (AC) type V isoform
      Primary Target IC<sub>50</sub>8.3 µM, 132 µM and 1.7 mM for type V, III and II, of adenylyl cyclase (AC), respectively, in the presence of Gsα GTPγS-Forskolin
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      116850-5MGCN 04055977208313

      Documentation

      Adenylyl Cyclase Type V Inhibitor, NKY80 - CAS 299442-43-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      116850

      References

      Reference overview
      Onda, T., et al. 2001. J. Biol. Chem. 276, 47785.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-April-2011 RFH
      Synonyms2-Amino-7-(furanyl)-7,8-dihydro-5(6H)-quinazolinone
      DescriptionA cell-permeable, non-nucleoside compound that acts as a potent, and selective inhibitor of adenylyl cyclase (AC) type V (IC50 = 8.3 µM, 132 µM and 1.7 mM for type V, III and II, respectively) in the presence of G5α GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Reported to regulate AC catalytic activity in heart and lung tissues.
      FormPale orange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number299442-43-6
      Chemical formulaC₁₂H₁₁N₃O₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (200 mg/ml) or Methanol (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesOnda, T., et al. 2001. J. Biol. Chem. 276, 47785.