04-262 Anti-Ubiquitinylated proteins Antibody, clone FK1

04-262
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      AWB, IHCMPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-262
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Ubiquitinylated proteins Antibody, clone FK1
      OverviewUbiquitin is a polypeptide of 76 amino acid residues, being a very highly conserved and widely distributed protein in all eukaryotic cells. It has been proposed that ubiquitin plays important roles in various biological processes such as the regulation of cell cycle, DNA replication, DNA repair, stress response, apoptosis, signal transduction, and the biogenesis of ribosome, nucleosome, peroxisome and myofibrils. In these processes, ubiquitin functions as both a signal for protein degradation and as a chaperone promoting the formation of organelles.
      References
      Product Information
      FormatPurified
      Presentation100 µL of concentration 1mg/mL purified immunoglobulin in PBS containing 0.1% sodium azide. Dilute to working strength with phosphate buffered saline pH 7.2-7.4.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Ubiquitinylated proteins Antibody, clone FK1 is an antibody against Ubiquitinylated proteins for use in WB, IH.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Biological Information
      ImmunogenPoly-ubiquitinylated-lysozyme.
      CloneFK1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityRecognizes only poly-ubiquitinylated proteins and not mono-ubiquitinylated proteins or free ubiquitin.
      IsotypeIgM
      Species Reactivity
      • All
      Antibody TypeMonoclonal Antibody
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of shipment for up to 12 months.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Ubiquitinylated proteins Antibody, clone FK1 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Ubiquitinylated proteins Antibody, clone FK1 Certificates of Analysis

      TitleLot Number
      Anti-Ubiquitinylated Proteins, clone FK13054660
      Anti-Ubiquitinylated Proteins, clone FK1 (mouse monoclonal IgM) - 21179762117976
      Anti-Ubiquitinylated Proteins, clone FK1 (mouse monoclonal IgM)2906533
      Anti-Ubiquitinylated Proteins, clone FK1 (mouse monoclonal IgM)3116910
      Anti-Ubiquitinylated Proteins, clone FK1 (mouse monoclonal IgM)3122972
      Anti-Ubiquitinylated Proteins, clone FK1 (mouse monoclonal IgM)2984247
      Anti-Ubiquitinylated Proteins, clone FK1 (mouse monoclonal IgM) - 20614172061417
      Anti-Ubiquitinylated Proteins, clone FK1 (mouse monoclonal IgM) - 22626112262611
      Anti-Ubiquitinylated Proteins, clone FK1 (mouse monoclonal IgM) - 22726742272674
      Anti-Ubiquitinylated Proteins, clone FK1 (mouse monoclonal IgM) - NG1938992NG1938992

      References

      Reference overviewPub Med ID
      Proteasome Inhibition Alleviates SNARE-Dependent Neurodegeneration.
      Sharma, Manu, et al.
      Sci Transl Med, 4: 147ra113 (2012)  2012

      Show Abstract
      22896677 22896677
      z-Leucinyl-leucinyl-norleucinal induces apoptosis of human glioblastoma tumor-initiating cells by proteasome inhibition and mitotic arrest response.
      Monticone M, Biollo E, Fabiano A, Fabbi M, Daga A, Romeo F, Maffei M, Melotti A, Giaretti W, Corte G, Castagnola P
      Molecular cancer research : MCR  7  1822-34  2009

      Show Abstract
      19861404 19861404
      Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation
      Haglund, Kaisa, et al
      Nat Cell Biol, 5:461-6 (2003)  2003

      12717448 12717448
      PI31 is a modulator of proteasome formation and antigen processing.
      Zaiss, Dietmar M W, et al.
      Proc. Natl. Acad. Sci. U.S.A., 99: 14344-9 (2002)  2002

      Show Abstract
      12374861 12374861
      Transient aggregation of ubiquitinated proteins during dendritic cell maturation.
      Lelouard, Hugues, et al.
      Nature, 417: 177-82 (2002)  2002

      Show Abstract
      12000969 12000969

      Data Sheet

      Title
      Anti-Ubiquitinylated Proteins, clone FK1