04-263 Anti-Ubiquitinylated proteins Antibody, clone FK2

04-263
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      AELISA, IF, IP, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-263
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Ubiquitinylated proteins Antibody, clone FK2
      Background InformationUbiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. Similarity: Belongs to the ubiquitin family. Contains 3 ubiquitin-like domains.
      References
      Product Information
      FormatPurified
      Presentation100 µL of purified immunoglobulin in PBS containing 0.1% sodium azide. Dilute to working strength with phosphate buffered saline pH 7.2-7.4.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Ubiquitinylated proteins Antibody, clone FK2 has been published and validated for use in ELISA, Immunofluorescence (IF), Immunoprecipitation (IP) and Western Blotting (WB) for the detection of Ubiquitinylated proteins.
      Key Applications
      • ELISA
      • Immunofluorescence
      • Immunoprecipitation
      • Western Blotting
      Biological Information
      ImmunogenPoly-ubiquitinylated-lysozyme.
      Cloneclone FK2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityRecognizes mono- and poly ubiquitinylated proteins, but not free ubiquitin.
      IsotypeIgG1
      Species Reactivity
      • All
      Antibody TypeMonoclonal Antibody
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of shipment for up to 12 months.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Ubiquitinylated proteins Antibody, clone FK2 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Ubiquitinylated proteins Antibody, clone FK2 Certificates of Analysis

      TitleLot Number
      Anti-PLCγ-1 -27843392784339
      Anti-Ubiquitinylated proteins, clone FK2 (mouse monoclonal IgG1) - 21189182118918
      Anti-Ubiquitinylated proteins, clone FK2 (mouse monoclonal IgG1) - 21385322138532
      Anti-Ubiquitinylated proteins, clone FK2 (mouse monoclonal IgG1) - 23821012382101
      Anti-Ubiquitinylated proteins, clone FK2 (mouse monoclonal IgG1) - 23864862386486
      Anti-Ubiquitinylated proteins, clone FK2 (mouse monoclonal IgG1) - 23888222388822
      Anti-Ubiquitinylated proteins, clone FK2 (mouse monoclonal IgG1) - 21421532142153
      Anti-Ubiquitinylated proteins, clone FK2 (mouse monoclonal IgG1)2883138
      Anti-Ubiquitinylated proteins, clone FK2 (mouse monoclonal IgG1)3117294
      Anti-Ubiquitinylated proteins, clone FK2 (mouse monoclonal IgG1)3035099

      References

      Reference overviewApplicationPub Med ID
      Characterization of aggregate/aggresome structures formed by polyhedrin of Bombyx mori nucleopolyhedrovirus.
      Guo, ZJ; Tao, LX; Dong, XY; Yu, MH; Tian, T; Tang, XD
      Scientific reports  5  14601  2015

      Show Abstract
      26440217 26440217
      Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth.
      Li, N; Zhang, Y; Han, X; Liang, K; Wang, J; Feng, L; Wang, W; Songyang, Z; Lin, C; Yang, L; Yu, Y; Chen, J
      Genes & development  29  157-70  2015

      Show Abstract
      25547115 25547115
      Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability.
      Viñas-Castells, R; Frías, Á; Robles-Lanuza, E; Zhang, K; Longmore, GD; García de Herreros, A; Díaz, VM
      Nucleic acids research  42  1079-94  2014

      Show Abstract
      24157836 24157836
      Tax posttranslational modifications and interaction with calreticulin in MT-2 cells and human peripheral blood mononuclear cells of human T cell lymphotropic virus type-I-associated myelopathy/tropical spastic paraparesis patients.
      Medina, F; Quintremil, S; Alberti, C; Barriga, A; Cartier, L; Puente, J; Ramírez, E; Ferreira, A; Tanaka, Y; Valenzuela, MA
      AIDS research and human retroviruses  30  370-9  2014

      Show Abstract
      Western Blotting24321043 24321043
      A two-step mechanism for TRF2-mediated chromosome-end protection.
      Okamoto, K; Bartocci, C; Ouzounov, I; Diedrich, JK; Yates, JR; Denchi, EL
      Nature  494  502-5  2013

      Show Abstract
      23389450 23389450
      Ubiquitination of the N-terminal region of caveolin-1 regulates endosomal sorting by the VCP/p97 AAA-ATPase.
      Kirchner, P; Bug, M; Meyer, H
      The Journal of biological chemistry  288  7363-72  2013

      Show Abstract
      23335559 23335559
      Regulation of the DNA damage response on male meiotic sex chromosomes.
      Lu, LY; Xiong, Y; Kuang, H; Korakavi, G; Yu, X
      Nature communications  4  2105  2013

      Show Abstract
      23812044 23812044
      Lysosome-mediated processing of chromatin in senescence.
      Ivanov, A; Pawlikowski, J; Manoharan, I; van Tuyn, J; Nelson, DM; Rai, TS; Shah, PP; Hewitt, G; Korolchuk, VI; Passos, JF; Wu, H; Berger, SL; Adams, PD
      The Journal of cell biology  202  129-43  2013

      Show Abstract
      Immunofluorescence23816621 23816621
      Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset.
      Listovsky, T; Sale, JE
      The Journal of cell biology  203  87-100  2013

      Show Abstract
      24100295 24100295
      Normal autophagic activity in macrophages from mice lacking Gαi3, AGS3, or RGS19.
      Vural, A; McQuiston, TJ; Blumer, JB; Park, C; Hwang, IY; Williams-Bey, Y; Shi, CS; Ma, DZ; Kehrl, JH
      PloS one  8  e81886  2013

      Show Abstract
      24312373 24312373