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239764 Cycloheximide, High Purity - CAS 66-81-9 - Calbiochem

239764
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Overview

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Key Spec Table

Empirical FormulaCAS #
C₁₅H₂₃NO₄66-81-9

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239764-100MGCN
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      Glass bottle 100 mg
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      Description
      OverviewAntifungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T cell hybridomas, Burkitt’s lymphoma cells, and a variety of other cell types including rodent macrophages. However, it inhibits DNA cleavage in rat thymocytes treated with Thapsigargin (Cat. No. 586005), methylprednisolone, and Ionomycin (Cat. Nos. 407950 and 407952). Rapidly destroyed in alkaline solutions. Also available as a 300 mM solution in DMSO (Cat. No. 508739).
      Catalogue Number239764
      Brand Family Calbiochem®
      References
      ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
      Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
      Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
      Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
      Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
      Waring, P. 1990. J. Biol. Chem. 265, 14476.
      Product Information
      CAS number66-81-9
      FormWhite solid
      Hill FormulaC₁₅H₂₃NO₄
      Chemical formulaC₁₅H₂₃NO₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationCycloheximide, High Purity, CAS 66-81-9, is an antifungal antibiotic that inhibits protein synthesis in eukaryotes. Interacts directly with a translocase and interferes with the translocation step.
      Biological Information
      Primary TargethFKBP12
      Primary Target K<sub>i</sub>3.4 µM
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSMA4375000
      Safety Information
      R PhraseR: 28-40-51/53-61

      Very toxic if swallowed.
      Limited evidence of a carcinogenic effect.
      Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
      May cause harm to the unborn child.
      S PhraseS: 45-53-61

      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Avoid exposure - obtain special instructions before use.
      Avoid release to the environment. Refer to special instructions/safety data sheet.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cycloheximide, High Purity - CAS 66-81-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      239764

      References

      Reference overview
      Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
      Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
      Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
      Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
      Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
      Waring, P. 1990. J. Biol. Chem. 265, 14476.

      Brochure

      Title
      Tools and Tips for Analyzing Apoptosis

      Citations

      Title
    • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-April-2008 RFH
      DescriptionAntifungal antibiotic that does not inhibit several species of pathogenic bacteria at 100 µg/ml. Inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFkBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells, and a variety of other cell types, including rodent macrophages. Inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.
      FormWhite solid
      CAS number66-81-9
      RTECSMA4375000
      Chemical formulaC₁₅H₂₃NO₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityChloroform, Ethanol, and Methanol
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 6 weeks at 4°C, pH 3-5.
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Merck USA index14, 2728
      ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
      Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
      Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
      Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
      Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
      Waring, P. 1990. J. Biol. Chem. 265, 14476.
      Citation
    • Hui Zeng, et al. (2005) Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. American Journal of Physiology Gastrointestinal and Liver Physiology in press,.