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324385 Doxycycline, Hyclate - CAS 24390-14-5 - Calbiochem

324385
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Overview

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Key Spec Table

Empirical FormulaCAS #
C₂₂H₂₄N₂O₈ · HCl · 1/2(H₂O) · 1/2(C₂H₆O)24390-14-5

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      Description
      OverviewA commonly-used broad-spectrum antibiotic. A potent inhibitor of MMP-8 (neutrophil collagenase; IC50 = 30 µM) relative to MMP-1 (interstitial collagenase; IC50 = 300 µM). Also inhibits collagen synthesis by bovine articular chondrocytes cultured in alginate (IC50 = 25 µM). Inhibits nitric oxide synthesis by LPS-activated macrophages without affecting IL-10 release.
      Catalogue Number324385
      Brand Family Calbiochem®
      Synonymsα-6-Deoxy-5-hydroxytetracycline, Vibramycin, Hyclate
      References
      ReferencesD’Agostino, P., et al. 1998. J. Infect. Dis. 177, 489.
      Beekman, B., et al. 1997. Biochem. Biophys. Res. Commun. 237, 107.
      Hanemaaijer, R., et al. 1997. J. Biol. Chem. 272, 31504.
      Lauhio, A., et al. 1994. Clin. Exp. Immunol. Antimicrobiol. Agents Chemother. 36, 227.
      Sorsa, T., et al. 1994. Ann. N.Y. Acad. Sci. 732, 112.
      Suomalainen, K., et al. 1992. Antimicrobiol. Agents Chemother. 36, 227.
      Product Information
      CAS number24390-14-5
      ATP CompetitiveN
      FormYellow to yellow-green crystalline solid
      Hill FormulaC₂₂H₂₄N₂O₈ · HCl · 1/2(H₂O) · 1/2(C₂H₆O)
      Chemical formulaC₂₂H₂₄N₂O₈ · HCl · 1/2(H₂O) · 1/2(C₂H₆O)
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationDoxycycline, Hyclate, CAS 24390-14-5, is a broad-spectrum antibiotic that acts as an inhibitor of MMP-8 (IC50 = 30 µM) relative to MMP-1 (IC50 = 300 µM).
      Biological Information
      Primary TargetMMP-8
      Primary Target IC<sub>50</sub>30 µM against MMP-8 (neutrophil collagenase); 25 µM inhibiting collagen synthesis by bovine articular chondrocytes cultured in alginate
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSQI8925000
      Safety Information
      R PhraseR: 20/21/22-63

      Harmful by inhalation, in contact with skin and if swallowed.
      Possible risk of harm to the unborn child.
      S PhraseS: 22-36

      Do not breathe dust.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollwing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 5 days at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Doxycycline, Hyclate - CAS 24390-14-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      324385

      References

      Reference overview
      D’Agostino, P., et al. 1998. J. Infect. Dis. 177, 489.
      Beekman, B., et al. 1997. Biochem. Biophys. Res. Commun. 237, 107.
      Hanemaaijer, R., et al. 1997. J. Biol. Chem. 272, 31504.
      Lauhio, A., et al. 1994. Clin. Exp. Immunol. Antimicrobiol. Agents Chemother. 36, 227.
      Sorsa, T., et al. 1994. Ann. N.Y. Acad. Sci. 732, 112.
      Suomalainen, K., et al. 1992. Antimicrobiol. Agents Chemother. 36, 227.

      Citations

      Title
    • Mark Cannon, Ethel Cesarman and Chris Boshoff. (2006) The KSHV G-protein coupled receptor inhibits lytic gene transcription in primary effusion lymphoma cells via p21-mediated inhibition of Cdk1. Blood 107, 277-284.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-March-2018 JSW
      Synonymsα-6-Deoxy-5-hydroxytetracycline, Vibramycin, Hyclate
      DescriptionA commonly used broad-spectrum antibiotic. A potent inhibitor of MMP-8 (neutrophil collagenase; IC50 = 30 µM) relative to MMP-1 (collagenase-1; IC50 = 300 µM). Also inhibits collagen synthesis by bovine articular chondrocytes cultured in alginate (IC50 = 25 µM). Inhibits nitric oxide synthesis by LPS-activated macrophages without affecting IL-10 release.
      FormYellow to yellow-green crystalline solid
      CAS number24390-14-5
      RTECSQI8925000
      Chemical formulaC₂₂H₂₄N₂O₈ · HCl · 1/2(H₂O) · 1/2(C₂H₆O)
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (50 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollwing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 5 days at 4°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      Merck USA index14, 3440
      ReferencesD’Agostino, P., et al. 1998. J. Infect. Dis. 177, 489.
      Beekman, B., et al. 1997. Biochem. Biophys. Res. Commun. 237, 107.
      Hanemaaijer, R., et al. 1997. J. Biol. Chem. 272, 31504.
      Lauhio, A., et al. 1994. Clin. Exp. Immunol. Antimicrobiol. Agents Chemother. 36, 227.
      Sorsa, T., et al. 1994. Ann. N.Y. Acad. Sci. 732, 112.
      Suomalainen, K., et al. 1992. Antimicrobiol. Agents Chemother. 36, 227.
      Citation
    • Mark Cannon, Ethel Cesarman and Chris Boshoff. (2006) The KSHV G-protein coupled receptor inhibits lytic gene transcription in primary effusion lymphoma cells via p21-mediated inhibition of Cdk1. Blood 107, 277-284.