328009 ERK Inhibitor III - CAS 331656-92-9 - Calbiochem

328009
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₂H₁₀N₆O₅331656-92-9

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328009-5MGCN
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      Glass bottle 5 mg
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      Description
      OverviewA cell-permeable furanyl-nitroaminoguanidine ERK-binding (KD = ~13 µM) compound that acts as a substrate-, but not ATP-, site-targeting inhibitor of ERK. Selectively inhibits the EGF-stimulated cellular phosphorylation of ERK substrates Rsk-1 and Elk-1, but not that of ERK1/2 or the anisomycin-induced phosphorylation of the p38 substrate ATP-2 in HeLa cells.
      Catalogue Number328009
      Brand Family Calbiochem®
      References
      ReferencesChen, F., et al. 2006. Bioorg. Med. Chem. Lett. 16, 6281.
      Product Information
      CAS number331656-92-9
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₂H₁₀N₆O₅
      Chemical formulaC₁₂H₁₀N₆O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetERK
      Primary Target IC<sub>50</sub>KD = ~13 µM against ERK
      Purity≥85% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      ERK Inhibitor III - CAS 331656-92-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      328009

      References

      Reference overview
      Chen, F., et al. 2006. Bioorg. Med. Chem. Lett. 16, 6281.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-April-2011 RFH
      DescriptionA cell-permeable furanyl-nitroaminoguanidine ERK-binding (KD of ~13 µM) compound that acts as a substrate-, but not ATP-, site-targeting inhibitor of ERK. Selectively inhibits the EGF-stimulated cellular phosphorylation of ERK substrates Rsk-1 and Elk-1, but not that of ERK1/2 or the anisomycin-induced phosphorylation of the p38 substrate ATP-2 in HeLa cells.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number331656-92-9
      Chemical formulaC₁₂H₁₀N₆O₅
      Structure formulaStructure formula
      Purity≥85% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesChen, F., et al. 2006. Bioorg. Med. Chem. Lett. 16, 6281.