371758 GPR81 Agonist, 3Cl-5OH-BA - CAS 53984-36-4 - Calbiochem

371758
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371758-100MGCN
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      Glass bottle 100 mg
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      Description
      OverviewA hydroxybenzoic acid compound that acts as a GPR81/HCA1-selective agonist (EC50 ~ 7, 16, 17, 22, and 67 µM toward rat, human, monkey, mouse, and dog species, respectively) with little activity towards the homologous GPR109A/HCA2/HM74A GPCR. Orally active in mice and exhibits NEFAc cholesterol-lowering efficacy in overnight fasted C57B16/J mice (ED50 ~100 mg/kg, p.o.) in vivo.
      Catalogue Number371758
      Brand Family Calbiochem®
      SynonymsHydroxycarboxylic Acid Receptor 1 Agonist, 3-Chloro-5-hydroxybenzoic acid
      References
      ReferencesDvorak, C.A., et al. 2012. ACS Med. Chem. Lett. 3, 637.
      Product Information
      CAS number53984-36-4
      FormLight beige solid
      Hill FormulaC₇H₅ClO₃
      Chemical formulaC₇H₅ClO₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGPR81
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      GPR81 Agonist, 3Cl-5OH-BA - CAS 53984-36-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      371758

      References

      Reference overview
      Dvorak, C.A., et al. 2012. ACS Med. Chem. Lett. 3, 637.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-May-2013 JSW
      SynonymsHydroxycarboxylic Acid Receptor 1 Agonist, 3-Chloro-5-hydroxybenzoic acid
      DescriptionA hydroxybenzoic acid compound that acts as a GPR81/HCA1-selective agonist (EC50 ~ 7, 16, 17, 22, and 67 µM toward rat, human, monkey, mouse, and dog species, respectively) with little activity towards the homologous GPR109A/HCA2/HM74A GPCR (EC50 >1 mM). Displays good pharmacokinetic characteristics in mice (Cmax/t1/2 = 67.2 µM/1.47 h and 341.9 µM/1.1 h, respectively, upon oral dosing at 30 mg/kg and 100 mg/kg) and exhibits NEFAc- (non-esterified free fatty acid cholesterol) lowering efficacy in overnight fasted C57B16/J mice (ED50 ~100 mg/kg, p.o.) in vivo.
      FormLight beige solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number53984-36-4
      Chemical formulaC₇H₅ClO₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesDvorak, C.A., et al. 2012. ACS Med. Chem. Lett. 3, 637.