371806 GTP-14564 - CAS 34823-86-4 - Calbiochem

371806
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₅H₁₀N₂O34823-86-4

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371806-5MGCN
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      Plastic ampoule 5 mg
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      Description
      OverviewA cell-permeable, reversible, and ATP-competitive tricyclic benzofurano-indazolo compound that acts as a potent and specific inhibitor of class III receptor tyrosine kinases (IC50 = 0.3 µM for c-fms, c-kit, wt-FLT3 and ITD-FLT3; 1.0 µM for PDGFRβ). Does not affect the activities of KDR, EGFR, HER2, Abl, Src, PKA, AKT, PKC, MEK, or ERK1/2 (IC50 ≥ 10 µM). Has been used successfully to differentiate between the signalling pathways activated by wt-FLT3 and ITD-FLT3 in Ba/F3 cells.
      Catalogue Number371806
      Brand Family Calbiochem®
      Synonyms1-Phenyl-3-H-8-oxa-2,3-diaza-cyclopenta[a]inden, 3-Phenyl-1H-benzofuro[3,2-c]pyrazole
      References
      ReferencesMurata, K., et al. 2003. J. Biol. Chem. 278, 32892.
      Product Information
      CAS number34823-86-4
      ATP CompetitiveY
      FormPale yellow solid
      Hill FormulaC₁₅H₁₀N₂O
      Chemical formulaC₁₅H₁₀N₂O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetClass III receptor tyrosine kinases
      Primary Target IC<sub>50</sub> 0.3 µM for c-fms, c-kit, wt-FLT3 and ITD-FLT3; 1.0 µM for PDGFRβ
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      GTP-14564 - CAS 34823-86-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      371806

      References

      Reference overview
      Murata, K., et al. 2003. J. Biol. Chem. 278, 32892.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-April-2018 JSW
      Synonyms1-Phenyl-3-H-8-oxa-2,3-diaza-cyclopenta[a]inden, 3-Phenyl-1H-benzofuro[3,2-c]pyrazole
      DescriptionA cell-permeable, reversible, ATP-competitive, and tricyclic, benzofurano-indazolo compound that acts as a potent and specific inhibitor of class III receptor tyrosine kinases (IC50 = 300 nM for c-fms, c-kit, wt-FLT3, and internal tandem duplication (ITD)-FLT3; 1 µM for PDGFRβ). Does not affect the activities of KDR, EGFR, HER2, Abl, Src, PKA, Akt, PKC, MEK, or ERK1/2 (IC50 >10 µM). Inhibits FLT-3 ligand-dependent growth of Ba/F3 cells expressing wild type FLT-3. Reported to be useful in differentiating signal transduction pathways activated by wt-FLT3 and ITD-FLT3 in Ba/F3 cells.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number34823-86-4
      Chemical formulaC₁₅H₁₀N₂O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesMurata, K., et al. 2003. J. Biol. Chem. 278, 32892.