508739 InSolution™ Cycloheximide, High Purity - CAS 66-81-9 - Calbiochem

508739
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₅H₂₃NO₄66-81-9

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      Glass bottle 100 mg
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      Description
      Catalogue Number508739
      Brand Family Calbiochem®
      Synonyms4-((R)-2-((1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)piperidine-2,6-dione, Actidione
      References
      ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
      Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
      Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
      Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
      Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
      Waring, P. 1990. J. Biol. Chem. 265, 14476.
      Product Information
      CAS number66-81-9
      FormLiquid
      FormulationA 300 mM (100 mg/1.185 ml) sterile-filtered solution of Cycloheximide, High Purity (Cat. No. 239764) in DMSO.
      Hill FormulaC₁₅H₂₃NO₄
      Chemical formulaC₁₅H₂₃NO₄
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      Biological Information
      Primary Targettranslocase enzyme
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 28-51/53-61

      Very toxic if swallowed.
      Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
      May cause harm to the unborn child.
      S PhraseS: 45-53-61

      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Avoid exposure - obtain special instructions before use.
      Avoid release to the environment. Refer to special instructions/safety data sheet.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      InSolution™ Cycloheximide, High Purity - CAS 66-81-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Christner, C., et al. 1999. J. Med. Chem. 42, 3615.
      Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
      Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
      Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
      Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
      Waring, P. 1990. J. Biol. Chem. 265, 14476.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-March-2014 JSW
      Synonyms4-((R)-2-((1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)piperidine-2,6-dione, Actidione
      DescriptionAntifungal antibiotic that does not inhibit several species of pathogenic bacteria at 100 µg/ml. Inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFkBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells, and a variety of other cell types, including rodent macrophages. Inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.
      FormLiquid
      FormulationA 300 mM (100 mg/1.185 ml) sterile-filtered solution of Cycloheximide, High Purity (Cat. No. 239764) in DMSO.
      CAS number66-81-9
      Chemical formulaC₁₅H₂₃NO₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage -20°C
      Hygroscopic
      Protect from light
      Avoid freeze/thaw
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      ReferencesChristner, C., et al. 1999. J. Med. Chem. 42, 3615.
      Lu, Q., et al. 1996. Arch. Biochem. Biophys. 334, 175.
      Chow, S.C., et al. 1995. Exp. Cell Res. 216, 149.
      Cotter, T.G., et al. 1992. Anticancer Res. 12, 773.
      Takano, Y.S., et al. 1991. J. Pathol. 163, 329.
      Waring, P. 1990. J. Biol. Chem. 265, 14476.