420130 JNK Inhibitor III, Cell-Permeable - Calbiochem

420130
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₉₁H₃₃₆N₇₀O₄₈S

Pricing & Availability

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420130-1MGCN
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      Plastic ampoule 1 mg
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      Description
      OverviewA cell-permeable 37-mer peptide constructed by fusing human c-Jun δ domain (amino acids 33-57) sequence with that of HIV-TAT protein transduction domain (amino acids 47-57) via a γ-aminobutyric acid (GABA) spacer. Shown to specifically disrupt c-Jun/JNK complex formation and the subsequent phosphorylation and activation of c-Jun by JNK both in vitro and in intact cells. Since its mode of inhibition is different than that of JNK Inhibitor II (SP600125; Cat. No. 420119), these two inhibitors can complement each other in JNK signaling pathway studies.
      Catalogue Number420130
      Brand Family Calbiochem®
      SynonymsSAPK Inhibitor III, HIV-TAT₄₇₋₅₇-gaba-c-Junδ₃₃₋₅₇, Ac-YGRKKRRQRRR-gaba-ILKQSMTLNLADPVGSLKPHLRAKN-NH₂
      References
      ReferencesHolzberg, D., et al. 2003. J. Biol. Chem. 278, 40213.
      Product Information
      ATP CompetitiveN
      FormLyophilized white solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₉₁H₃₃₆N₇₀O₄₈S
      Chemical formulaC₁₉₁H₃₃₆N₇₀O₄₈S
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetJNK
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceAc-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-gaba-Ile-Leu-Lys-Gln-Ser-Met-Thr-Leu-Asn-Leu-Ala-Asp-Pro-Val-Gly-Ser-Leu-Lys-Pro-His-Leu-Arg-Ala-Lys-Asn-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      JNK Inhibitor III, Cell-Permeable - Calbiochem Certificates of Analysis

      TitleLot Number
      420130

      References

      Reference overview
      Holzberg, D., et al. 2003. J. Biol. Chem. 278, 40213.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-July-2010 JSW
      SynonymsSAPK Inhibitor III, HIV-TAT₄₇₋₅₇-gaba-c-Junδ₃₃₋₅₇, Ac-YGRKKRRQRRR-gaba-ILKQSMTLNLADPVGSLKPHLRAKN-NH₂
      DescriptionA cell-permeable 37 amino acid peptide constructed by fusing the JNK binding domain sequence (δ) (amino acids 33-57) of human c-Jun to the HIV-TAT transduction domain sequence (amino acids 47-57) with a γ-aminobutyric acid (GABA) spacer. Reported to specifically disrupt c-Jun/JNK complex formation and subsequent phosphorylation and activation of c-Jun by JNK in vitro and in intact cells. Also reported to induce apoptosis in HeLa cells. Mode of inhibition is distinct from that of JNK Inhibitor II (SP600125; Cat. No. 420119), so may complement this inhibitor in JNK pathway studies.
      FormLyophilized white solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₉₁H₃₃₆N₇₀O₄₈S
      Peptide SequenceAc-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-gaba-Ile-Leu-Lys-Gln-Ser-Met-Thr-Leu-Asn-Leu-Ala-Asp-Pro-Val-Gly-Ser-Leu-Lys-Pro-His-Leu-Arg-Ala-Lys-Asn-NH₂
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml) or Acetic Acid (100 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesHolzberg, D., et al. 2003. J. Biol. Chem. 278, 40213.