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422706 KN-62 - CAS 127191-97-3 - Calbiochem

422706
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Key Spec Table

CAS #Empirical Formula
127191-97-3C₃₈H₃₅N₅O₆S₂

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422706-1MGCN
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      Description
      OverviewA cell-permeable, reversible, and selective inhibitor of CaM kinase II (Ki = 900 nM for rat brain CaM kinase II) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.
      Catalogue Number422706
      Brand Family Calbiochem®
      Synonyms1-[N,O-bis-(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, P2X Antagonist II, Purinergic Receptor P2X Antagonist II
      References
      ReferencesMinami, H., et al. 1994. Biochem. Biophys. Res. Commun. 199, 241.
      Kato, M., et al. 1992. Neurosci. Lett. 129, 47.
      Ishii, A., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1051.
      Ito, I., et al. 1991. Neurosci. Lett. 121, 119.
      Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
      Product Information
      CAS number127191-97-3
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₃₈H₃₅N₅O₆S₂
      Chemical formulaC₃₈H₃₅N₅O₆S₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcam kinase 2
      Primary Target K<sub>i</sub>900 nM for rat brain CaM kinase II
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      KN-62 - CAS 127191-97-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      KN-62 - CAS 127191-97-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      422706

      References

      Reference overview
      Minami, H., et al. 1994. Biochem. Biophys. Res. Commun. 199, 241.
      Kato, M., et al. 1992. Neurosci. Lett. 129, 47.
      Ishii, A., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1051.
      Ito, I., et al. 1991. Neurosci. Lett. 121, 119.
      Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-November-2009 RFH
      Synonyms1-[N,O-bis-(5-Isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, P2X Antagonist II, Purinergic Receptor P2X Antagonist II
      DescriptionA cell-permeable, reversible, and selective inhibitor of Ca2+/calmodulin-dependent protein kinase II (Ki = 900 nM for rat brain enzyme) that binds directly to the calmodulin binding site of the enzyme. Also inhibits the growth of K562 cells in a dose-dependent manner.
      FormOff-white solid
      CAS number127191-97-3
      Chemical formulaC₃₈H₃₅N₅O₆S₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO or Methanol (5 mg/ml). Further dilute with aqueous buffer just prior to use.
      Storage +2°C to +8°C
      Protect from moisture
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.
      Toxicity Standard Handling
      ReferencesMinami, H., et al. 1994. Biochem. Biophys. Res. Commun. 199, 241.
      Kato, M., et al. 1992. Neurosci. Lett. 129, 47.
      Ishii, A., et al. 1991. Biochem. Biophys. Res. Commun. 176, 1051.
      Ito, I., et al. 1991. Neurosci. Lett. 121, 119.
      Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.