505770 LSD1 Inhibitor VI, Cpd 2d - Calbiochem

505770
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₄₇H₆₈N₁₂

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      Glass bottle 5 mg
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      Description
      OverviewA cell-permeable polyamine derivative that acts as an inhibitor of lysine-specific demethylase-1 (LSD1, KDM1) and increases levels of mono- and di-methylated histone H3K4, H3K9 proteins in acute myeloid leukemia (AML) cancer cells in a dose-dependent manner. Shown to cause significant growth inhibition in different AML cell lines (HL-60, KG1a, HNT-34, and ML-1 cells) at low micromolar concentrations (5 to 10 µM) over a period of 96 hours. Induces re-expression of cancer suppressing E-caherin gene and CDH-1 mRNA in tumor cells (˜10 µM). Also, displays anti-trypanosomal properties and inhibits trypanothione reductase activity (IC50 = 950 nM) in Trypanosoma brucei brucei.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number505770
      Brand Family Calbiochem®
      Synonyms1,15-bis{N5-[3,3-(diphenyl)propyl]-N1-biguanido}-4,12-diazapentadecane
      References
      ReferencesMurray-Stewart, T., et al. 2013, Amino Acids 44, in press.
      Bi, X. et al. 2006, Bioorg. Med. Chem. Lett. 16,3229.
      Product Information
      FormOff-white solid
      Hill FormulaC₄₇H₆₈N₁₂
      Chemical formulaC₄₇H₆₈N₁₂
      Hygroscopic Hygroscopic
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetLSD1
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      LSD1 Inhibitor VI, Cpd 2d - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Murray-Stewart, T., et al. 2013, Amino Acids 44, in press.
      Bi, X. et al. 2006, Bioorg. Med. Chem. Lett. 16,3229.

      Brochure

      Title
      NPI Flyer- Epigenetics and Nuclear Function Feature
      New Products - Antibodies, Small Molecule, Inhibitors (MM)

      Technical Info

      Title
      White Paper: Further considerations of antibody validation and usage.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-September-2014 JSW
      Synonyms1,15-bis{N5-[3,3-(diphenyl)propyl]-N1-biguanido}-4,12-diazapentadecane
      DescriptionA cell-permeable polyamine derivative that acts as an inhibitor of lysine-specific demethylase-1 (LSD1, KDM1) and increases levels of mono- and di-methylated histone H3K4, H3K9 proteins in acute myeloid leukemia (AML) cancer cells in a dose-dependent manner. Shown to cause significant growth inhibition in different AML cell lines (HL-60, KG1a, HNT-34, and ML-1 cells) at low micromolar concentrations (5 to 10 µM) over a period of 96 hours. Induces re-expression of cancer suppressing E-caherin gene and CDH-1 mRNA in tumor cells (˜10 µM). Also, displays anti-trypanosomal properties and inhibits trypanothione reductase activity (IC50 = 950 nM) in Trypanosoma brucei brucei.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₄₇H₆₈N₁₂
      Purity≥98% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesMurray-Stewart, T., et al. 2013, Amino Acids 44, in press.
      Bi, X. et al. 2006, Bioorg. Med. Chem. Lett. 16,3229.