440206 LY 294002, 4ʹ-NH₂ - CAS 942289-87-4 - Calbiochem

440206
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Key Spec Table

Empirical FormulaCAS #
C₁₉H₁₈N₂O₃942289-87-4

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440206-5MGCN
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      Plastic ampoule 5 mg
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      Description
      OverviewA cell-permeable LY 294002 (Cat. Nos. 440202 & 440204) 4′-amino derivative with enhanced potency against p110α/β/δ/γ (IC50 in nM/-fold increase in potency = 183/2.7-, 98/5.7-, 1227/.5-, and 1967/1.9-, respectively). The molecule has been immobilized on epoxy-containing solid surface via the 4'-amine for binding studies and shown to interact with non-PI3K cellular proteins, such as mTOR, ALDH1, Brd4, GSK3β, and CKIIα.
      Catalogue Number440206
      Brand Family Calbiochem®
      Synonyms2-(4-Morpholinyl)-8-(4-aminophenyl)-4H-1-benzopyrone-4-one, PI-828
      References
      ReferencesGharbi, S.I., et al., 2007. Biochem. J. 404, 15.
      Product Information
      CAS number942289-87-4
      FormOff-white solid
      Hill FormulaC₁₉H₁₈N₂O₃
      Chemical formulaC₁₉H₁₈N₂O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25-36/37/39

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      LY 294002, 4ʹ-NH₂ - CAS 942289-87-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      440206

      References

      Reference overview
      Gharbi, S.I., et al., 2007. Biochem. J. 404, 15.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-April-2009 RFH
      Synonyms2-(4-Morpholinyl)-8-(4-aminophenyl)-4H-1-benzopyrone-4-one, PI-828
      DescriptionA cell-permeable LY 294002 (Cat. Nos. 440202 & 440204) 4′-amino derivative with enhanced potency against p110α/β/δ/γ (IC50 in nM/-fold increase in potency = 183/2.7-, 98/5.7-, 1227/.5-, and 1967/1.9-, respectively). The molecule has been immobilized on epoxy-containing solid surface via the 4'-amine for binding studies and shown to interact with non-PI3K cellular proteins, such as mTOR, ALDH1, Brd4, GSK3β, and CKIIα.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number942289-87-4
      Chemical formulaC₁₉H₁₈N₂O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (30 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesGharbi, S.I., et al., 2007. Biochem. J. 404, 15.