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454861 MNK1 Inhibitor - CAS 522629-08-9 - Calbiochem

454861
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
522629-08-9C₁₁H₉FN₆

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454861-5MGCN
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      Description
      OverviewA cell-permeable, reversible, and ATP-competitive pyrazolo-pyrimidine compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 1 (MNK1; IC50 = 2.2 µM) with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. Effectively inhibits eIF4E phosphorylation (IC50 = 3 µM) by MNK1 in 293 human embryonic kidney cells and serves as a useful tool in studying MNK1-mediated cellular signaling.
      Catalogue Number454861
      Brand Family Calbiochem®
      Synonyms4-Amino-5-(4-fluoroanilino)-pyrazolo[3,4-d]pyrimidine, MNK Inhibitor I, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor I, CGP 57380
      References
      ReferencesTopisirovic, I., et al. 2004. Cancer Res. 64, 8639.
      Worch, J., et al. 2004. Oncogene 23, 9162.
      Walsh, D., and Mohr, I. 2004. Genes Dev. 18, 660.
      Morley, S.J., and Naegele, S. 2002. J. Biol. Chem. 277, 32855.
      Knauf, U., et al. 2001. Mol. Cell. Biol. 21, 5500.
      Product Information
      CAS number522629-08-9
      ATP CompetitiveY
      FormOff-white solid
      Hill FormulaC₁₁H₉FN₆
      Chemical formulaC₁₁H₉FN₆
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMitogen-activated protein kinase-interacting kinase 1 (MNK1)
      Primary Target IC<sub>50</sub>2.2 µM against mitogen-activated protein kinase-interacting kinase 1 (MNK1); 3 µM against eIF4E phosphorylation by MNK1 in 293 human embryonic kidney cells
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      MNK1 Inhibitor - CAS 522629-08-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      MNK1 Inhibitor - CAS 522629-08-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      454861

      References

      Reference overview
      Topisirovic, I., et al. 2004. Cancer Res. 64, 8639.
      Worch, J., et al. 2004. Oncogene 23, 9162.
      Walsh, D., and Mohr, I. 2004. Genes Dev. 18, 660.
      Morley, S.J., and Naegele, S. 2002. J. Biol. Chem. 277, 32855.
      Knauf, U., et al. 2001. Mol. Cell. Biol. 21, 5500.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-September-2012 JSW
      Synonyms4-Amino-5-(4-fluoroanilino)-pyrazolo[3,4-d]pyrimidine, MNK Inhibitor I, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor I, CGP 57380
      DescriptionA cell-permeable, reversible, and ATP-competitive pyrazolo-pyrimidine compound that acts as a selective inhibitor of mitogen-activated protein kinase-interacting kinase 1 (MNK1; IC50 = 2.2 µM) with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. Effectively inhibits eIF4E phosphorylation (IC50 = 3 µM) by MNK1 in 293 human embryonic kidney cells and serves as a useful tool in studying MNK1-mediated cellular signaling.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number522629-08-9
      Chemical formulaC₁₁H₉FN₆
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (15 mg/ml) or Ethanol (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Toxic
      ReferencesTopisirovic, I., et al. 2004. Cancer Res. 64, 8639.
      Worch, J., et al. 2004. Oncogene 23, 9162.
      Walsh, D., and Mohr, I. 2004. Genes Dev. 18, 660.
      Morley, S.J., and Naegele, S. 2002. J. Biol. Chem. 277, 32855.
      Knauf, U., et al. 2001. Mol. Cell. Biol. 21, 5500.