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475886 NG-Monomethyl-L-arginine, Monoacetate Salt - CAS 53308-83-1 - Calbiochem

475886
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Overview

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Key Spec Table

CAS #Empirical Formula
53308-83-1C₇H₁₆N₄O₂ · CH₃CO₂H

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475886-100MGCN
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      Description
      OverviewCell permeable. L-Arginine analog that acts as a competitive inhibitor of all three isoforms of nitric oxide synthase (Ki = 700 nM for eNOS; Ki = 3.9 µM for iNOS; Ki = 650 nM for nNOS). Inhibits histamine- and acetylcholine-induced relaxation (Ki = 9.5 µM) of intact norepinephrine-constricted guinea pig pulmonary artery.
      Catalogue Number475886
      Brand Family Calbiochem®
      SynonymsNω-Me-L-Arg, NG-Me-L-Arg, AcOH, L-NMMA
      References
      ReferencesReif, D.W., and McCreedy, S.A. 1995. Arch. Biochem. Biophys. 320, 170.
      O’Kane, K.P., et al. 1994. Br. J. Clin. Pharmacol. 38, 311.
      Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4651.
      Mehta, J.L., et al. 1990. Biochem. Biophys. Res. Commun. 173, 438.
      Thomas, G., et al. 1989. Biochem. Biophys. Res. Commun. 158, 177.
      Sakuma, I., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 8664.
      Hibbs, J.B., et al. 1987. Science 237, 473.
      Palmer, R.M.J., et al. 1987. Nature 327, 524.
      Product Information
      CAS number53308-83-1
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₇H₁₆N₄O₂ · CH₃CO₂H
      Chemical formulaC₇H₁₆N₄O₂ · CH₃CO₂H
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargeteNOS
      Primary Target K<sub>i</sub>700 nM for eNOS; 3.9 µM for iNOS; 650 nM for nNOS
      Purity≥99% by TLC; ≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +15°C to +30°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 4 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      NG-Monomethyl-L-arginine, Monoacetate Salt - CAS 53308-83-1 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      NG-Monomethyl-L-arginine, Monoacetate Salt - CAS 53308-83-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      475886

      References

      Reference overview
      Reif, D.W., and McCreedy, S.A. 1995. Arch. Biochem. Biophys. 320, 170.
      O’Kane, K.P., et al. 1994. Br. J. Clin. Pharmacol. 38, 311.
      Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4651.
      Mehta, J.L., et al. 1990. Biochem. Biophys. Res. Commun. 173, 438.
      Thomas, G., et al. 1989. Biochem. Biophys. Res. Commun. 158, 177.
      Sakuma, I., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 8664.
      Hibbs, J.B., et al. 1987. Science 237, 473.
      Palmer, R.M.J., et al. 1987. Nature 327, 524.

      Brochure

      Title
      Pathways and Biomarkers of Oxidative Stress

      Citations

      Title
    • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
    • Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-August-2008 RFH
      SynonymsNω-Me-L-Arg, NG-Me-L-Arg, AcOH, L-NMMA
      DescriptionL-Arginine analog that acts as a cell-permeable, competitive inhibitor of all three isoforms of nitric oxide synthase (NOS) (Ki = 650 nM for nNOS; Ki = 700 nM for eNOS; Ki = 3.9 µM for iNOS). Inhibits histamine- and acetylcholine-induced relaxation (Ki = 9.5 µM) of intact norepinephrine-constricted guinea pig pulmonary artery.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number53308-83-1
      Chemical formulaC₇H₁₆N₄O₂ · CH₃CO₂H
      Structure formulaStructure formula
      Purity≥99% by TLC; ≥99% by HPLC
      SolubilityH₂O (50 mg/ml) or Methanol
      Storage +15°C to +30°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 4 months at -20°C.
      Toxicity Standard Handling
      ReferencesReif, D.W., and McCreedy, S.A. 1995. Arch. Biochem. Biophys. 320, 170.
      O’Kane, K.P., et al. 1994. Br. J. Clin. Pharmacol. 38, 311.
      Kubes, P., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 4651.
      Mehta, J.L., et al. 1990. Biochem. Biophys. Res. Commun. 173, 438.
      Thomas, G., et al. 1989. Biochem. Biophys. Res. Commun. 158, 177.
      Sakuma, I., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 8664.
      Hibbs, J.B., et al. 1987. Science 237, 473.
      Palmer, R.M.J., et al. 1987. Nature 327, 524.
      Citation
    • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.