508119 SB 399885 Hydrochloride - CAS 402713-80-8 - Calbiochem

508119
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Key Spec Table

Empirical FormulaCAS #
C₁₈H₂₁Cl₂N₃O₄S·HCl402713-80-8

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      Glass bottle 10 mg
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      Description
      OverviewA high affinity 5-HT6 Receptor antagonist (pKi = 9.0). Good solubility (to 100 mM in water or DMSO), oral availability, and penetrant to blood brain barrier. Over 200-fold selective for 5-HT6 receptors vs all receptors, ion channels and enzymes tested in Hirst et al. 2006 publication. Shows nootropic, antidepressant and axiolytic effects comparable to well-described drugs such as diazepam, and therefore has been proposed as novel treatment for schizoprenia and Alzheimer′s disease.
      Catalogue Number508119
      Brand Family Calbiochem®
      Synonyms5-HT₆ Receptor antagonist, SB 399885 Hydrochloride, SB-399885, SB399885
      References
      ReferencesWesolowska, A. et al. 2007. Pharmacol Rep. 59, 664.
      Li, Z. et al. 2007. Brain Res. 1134, 70.
      Hirst, et al. 2006. Eur. J. Pharm. 553, 109.
      Routledge, C. et al. 2000. Br. J. Pharmacol. 130, 1606.
      Product Information
      CAS number402713-80-8
      FormWhite solid
      Hill FormulaC₁₈H₂₁Cl₂N₃O₄S·HCl
      Chemical formulaC₁₈H₂₁Cl₂N₃O₄S·HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target5-HT₆
      Primary Target K<sub>i</sub>1 nM
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SB 399885 Hydrochloride - CAS 402713-80-8 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Wesolowska, A. et al. 2007. Pharmacol Rep. 59, 664.
      Li, Z. et al. 2007. Brain Res. 1134, 70.
      Hirst, et al. 2006. Eur. J. Pharm. 553, 109.
      Routledge, C. et al. 2000. Br. J. Pharmacol. 130, 1606.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-October-2013 JSW
      Synonyms5-HT₆ Receptor antagonist, SB 399885 Hydrochloride, SB-399885, SB399885
      DescriptionA high affinity 5-HT6 Receptor antagonist (pKi = 9.0). Good solubility (to 100 mM in water or DMSO), oral availability, and penetrant to blood brain barrier. Over 200-fold selective for 5-HT6 receptors vs all receptors, ion channels and enzymes tested in Hirst et al. 2006 publication. Shows nootropic, antidepressant and axiolytic effects comparable to well-described drugs such as diazepam, and therefore has been proposed as novel treatment for schizoprenia and Alzheimer′s disease.
      FormWhite solid
      CAS number402713-80-8
      Chemical formulaC₁₈H₂₁Cl₂N₃O₄S·HCl
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (100 mM) or H₂O (100 mM)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesWesolowska, A. et al. 2007. Pharmacol Rep. 59, 664.
      Li, Z. et al. 2007. Brain Res. 1134, 70.
      Hirst, et al. 2006. Eur. J. Pharm. 553, 109.
      Routledge, C. et al. 2000. Br. J. Pharmacol. 130, 1606.