508149 SB 699551 Dihydrochloride - CAS 791789-61-2 - Calbiochem

508149
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Key Spec Table

Empirical FormulaCAS #
C₃₄H₄₅N₃O·2HCl791789-61-2

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      Glass bottle 10 mg
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      Description
      OverviewA selective, brain penetrant, 5-HT5A receptor antagonis (pKi = 8.2). Competitively antagonised 5-HT-stimulated [35S]GTPγS binding to membranes from human embryonic kidney (HEK293) cells transiently expressing the guinea pig 5-HT5A receptor (pA2 8.1 ± 0.1) and displayed 100-fold selectivity versus the serotonin transporter and those 5-HT receptor subtypes (5-HT1A/B/D, 5-HT2A/C and 5-5-HT7).
      Catalogue Number508149
      Brand Family Calbiochem®
      Synonyms5-HT5A Serotonin Receptor Antagonist, SB 699551, SB 699551, SB699551, SB-699551
      References
      ReferencesFerenc, K. et al. 2012. Behav. Pharmacol. 23, 397.
      Thomas, D. R. et al. 2006. Neuropharmacol. 51, 566.
      Corbett, D. F. et al. 2005. Bioorg. Med. Chem. Lett. 15, 4014.
      Product Information
      CAS number791789-61-2
      FormWhite solid
      Hill FormulaC₃₄H₄₅N₃O·2HCl
      Chemical formulaC₃₄H₄₅N₃O·2HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target5-HT5A
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SB 699551 Dihydrochloride - CAS 791789-61-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Ferenc, K. et al. 2012. Behav. Pharmacol. 23, 397.
      Thomas, D. R. et al. 2006. Neuropharmacol. 51, 566.
      Corbett, D. F. et al. 2005. Bioorg. Med. Chem. Lett. 15, 4014.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-October-2013 JSW
      Synonyms5-HT5A Serotonin Receptor Antagonist, SB 699551, SB 699551, SB699551, SB-699551
      DescriptionA selective, brain penetrant, 5-HT5A receptor antagonis (pKi = 8.2). Competitively antagonised 5-HT-stimulated [35S]GTPγS binding to membranes from human embryonic kidney (HEK293) cells transiently expressing the guinea pig 5-HT5A receptor (pA2 8.1 ± 0.1) and displayed 100-fold selectivity versus the serotonin transporter and those 5-HT receptor subtypes (5-HT1A/B/D, 5-HT2A/C and 5-5-HT7).
      FormWhite solid
      CAS number791789-61-2
      Chemical formulaC₃₄H₄₅N₃O·2HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (25 mM) or Ethanol (10 mM)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesFerenc, K. et al. 2012. Behav. Pharmacol. 23, 397.
      Thomas, D. R. et al. 2006. Neuropharmacol. 51, 566.
      Corbett, D. F. et al. 2005. Bioorg. Med. Chem. Lett. 15, 4014.