567305 SKF-86002 - CAS 72873-74-6 - Calbiochem

567305
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₆H₁₂FN₃S72873-74-6

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567305-5MGCN
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      Plastic ampoule 5 mg
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      Description
      OverviewA cell-permeable, reversible, and ATP-competitive cytokine-suppressive anti-inflammatory drug (CSAID). A bicyclic imidazole that inhibits lipolysaccharide (LPS)-stimulated human monocyte IL-1 and TNF-α production (IC50 = 1 µM). Also acts as an inhibitor of both cyclooxygenase and 5-lipoxygenase. SKF-86002 also acts as a specific p38 MAP kinase inhibitor.
      Catalogue Number567305
      Brand Family Calbiochem®
      Synonyms6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridyl)imidazo[2,1-b]thiazole
      References
      ReferencesFrasch, S.C., et al. 1998. J. Biol. Chem. 273, 8389.
      Blanque, R., et al. 1997. Drugs Exp. Clin. Res. 23, 63.
      Lee, J.C., et al. 1995. Nature 372, 739.
      Prichett, W., et al. 1995. J. Inflamm. 45, 97.
      Lee, J.C., et al. 1993. Ann. N.Y. Acad. Sci. 696, 149.
      Product Information
      CAS number72873-74-6
      ATP CompetitiveY
      FormOff-white solid
      Hill FormulaC₁₆H₁₂FN₃S
      Chemical formulaC₁₆H₁₂FN₃S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target(LPS)-stimulated IL-1 and TNF-α production
      Primary Target IC<sub>50</sub>1 µM inhibiting lipolysaccharide (LPS)-stimulated human monocyte IL-1 and TNF-α production
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      SKF-86002 - CAS 72873-74-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      567305

      References

      Reference overview
      Frasch, S.C., et al. 1998. J. Biol. Chem. 273, 8389.
      Blanque, R., et al. 1997. Drugs Exp. Clin. Res. 23, 63.
      Lee, J.C., et al. 1995. Nature 372, 739.
      Prichett, W., et al. 1995. J. Inflamm. 45, 97.
      Lee, J.C., et al. 1993. Ann. N.Y. Acad. Sci. 696, 149.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-September-2008 RFH
      Synonyms6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridyl)imidazo[2,1-b]thiazole
      DescriptionA cytokine-suppressive anti-inflammatory drug (CSAID). A bicyclic imidazole that inhibits lipolysaccharide (LPS)-stimulated human monocyte IL-1 and TNF-α production (IC50 = 1 µM). Also acts as an inhibitor of both cyclooxygenase and 5-lipoxygenase. SKF-86002 also acts as a specific p38 MAP kinase inhibitor.
      FormOff-white solid
      CAS number72873-74-6
      Chemical formulaC₁₆H₁₂FN₃S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Toxicity Irritant
      ReferencesFrasch, S.C., et al. 1998. J. Biol. Chem. 273, 8389.
      Blanque, R., et al. 1997. Drugs Exp. Clin. Res. 23, 63.
      Lee, J.C., et al. 1995. Nature 372, 739.
      Prichett, W., et al. 1995. J. Inflamm. 45, 97.
      Lee, J.C., et al. 1993. Ann. N.Y. Acad. Sci. 696, 149.