533574 TRPML3 Activator, ML123 - Calbiochem

533574
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₆H₂₃ClN₂O₃S

Pricing & Availability

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      Glass bottle 25 mg
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      Description
      OverviewA non-cytotoxic morpholinyl-cyclohexylbenzenesulfonamide compound that acts as a selective agonist of TRPML3 channel (EC50 = 873 nM in hTRPML3-YPF transfected HEK293 cells). Displays significantly weaker agonistic activity for TRPML2 channel (54.5% at 10 µM) and is shown to be inactive against hTRPML1, hTRPM2, mTRPV2, hTRPC3, drTRPN1, and hTRPA1 (~10 µM). Also binds to sigma-1 receptor at much higher concentrations (IC50 = 31 µM).
      Catalogue Number533574
      Brand Family Calbiochem®
      Synonyms4-Chloro-N-(2-morpholinocyclohexyl)benzenesulfonamide, SF-21, CID2911646, ML123, ML 123, Transient Receptor Potential Channel 3 Activator, SID24801657, Racemate, SR-1984
      References
      ReferencesAntolin, A.A., and Mestres, J. 2015. ACS Chem. Biol. 10, 395.
      Grimm, C., et al. 2012. J. Biol. Chem. 287, 22701.
      Saldanha, S., et al. 2010. Probe Reports from the NIH Molecular Libraries Program.
      Grimm, C., et al. 2010. Chem. Biol. 17, 135.
      Product Information
      FormOff-white solid
      Hill FormulaC₁₆H₂₃ClN₂O₃S
      Chemical formulaC₁₆H₂₃ClN₂O₃S
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTRPML3
      Purity≥92% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      TRPML3 Activator, ML123 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Antolin, A.A., and Mestres, J. 2015. ACS Chem. Biol. 10, 395.
      Grimm, C., et al. 2012. J. Biol. Chem. 287, 22701.
      Saldanha, S., et al. 2010. Probe Reports from the NIH Molecular Libraries Program.
      Grimm, C., et al. 2010. Chem. Biol. 17, 135.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-July-2016 JSW
      Synonyms4-Chloro-N-(2-morpholinocyclohexyl)benzenesulfonamide, SF-21, CID2911646, ML123, ML 123, Transient Receptor Potential Channel 3 Activator, SID24801657, Racemate, SR-1984
      DescriptionA non-cytotoxic morpholinyl-cyclohexylbenzenesulfonamide compound that acts as a selective agonist of TRPML3 channel (EC50 = 873 nM in hTRPML3-YPF transfected HEK293 cells). Displays significantly weaker agonistic activity for TRPML2 channel (54.5% at 10 µM) and is shown to be inactive against hTRPML1, hTRPM2, mTRPV2, hTRPC3, drTRPN1, and hTRPA1 (~10 µM). Also binds to sigma-1 receptor at much higher concentrations (IC50 = 31 µM).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₆H₂₃ClN₂O₃S
      Purity≥92% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesAntolin, A.A., and Mestres, J. 2015. ACS Chem. Biol. 10, 395.
      Grimm, C., et al. 2012. J. Biol. Chem. 287, 22701.
      Saldanha, S., et al. 2010. Probe Reports from the NIH Molecular Libraries Program.
      Grimm, C., et al. 2010. Chem. Biol. 17, 135.