610225 Tigecycline - CAS 220620-09-7 - Calbiochem

610225
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₉H₃₉N₅O₈220620-09-7

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610225-50MGCN
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      Glass bottle 50 mg
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      Description
      OverviewA broad-spectrum glyclcycline class of antimicrobial agent that is active against both Gram positive and Gram negative bacteria. Exhibits toxicity for human AML cells at all stages of development in both in vitro and in vivo models. Selectively kills leukemic stem and progenitor cells (LD50 ~10 µM) and reduces the repopulating ability of the primary AML cells while sparing normal hematopoietic cells. Its action on growth and viability of eukaryotic cells is shown to be due to its inhibitory effects on mitochondrial protein translation and respiratory complex activity.
      Catalogue Number610225
      Brand Family Calbiochem®
      Synonyms9-t-Butylglycylamido-minocycline
      References
      ReferencesSkrtic, M., et al. 2011. Cancer Cell 20, 674.
      Olson, M.W., et al. 2006. Antimicrob. Agents Chemother. 50, 2156.
      Stein, G.E., and Craig, W.A., 2006. Clin. Infect Dis. 43, 518.
      Livermore, D.M., 2005. J. Antimicrob. Chemother. 56, 611.
      Product Information
      CAS number220620-09-7
      FormOrange powder
      Hill FormulaC₂₉H₃₉N₅O₈
      Chemical formulaC₂₉H₃₉N₅O₈
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36-60-61

      Irritating to eyes.
      May impair fertility.
      May cause harm to the unborn child.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Tigecycline - CAS 220620-09-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      610225

      References

      Reference overview
      Skrtic, M., et al. 2011. Cancer Cell 20, 674.
      Olson, M.W., et al. 2006. Antimicrob. Agents Chemother. 50, 2156.
      Stein, G.E., and Craig, W.A., 2006. Clin. Infect Dis. 43, 518.
      Livermore, D.M., 2005. J. Antimicrob. Chemother. 56, 611.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-July-2012 JSW
      Synonyms9-t-Butylglycylamido-minocycline
      DescriptionA broad-spectrum glyclcycline class of antimicrobial agent that is active against both Gram positive and Gram negative bacteria. Exhibits toxicity for human AML cells at all stages of development in both in vitro and in vivo models. Selectively kills leukemic stem and progenitor cells (LD50 ~10 µM) and reduces the repopulating ability of the primary AML cells while sparing normal hematopoietic cells. Its action on growth and viability of eukaryotic cells is shown to be due to its inhibitory effects on mitochondrial protein translation and respiratory complex activity.
      FormOrange powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number220620-09-7
      Chemical formulaC₂₉H₃₉N₅O₈
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO
      Storage +2°C to +8°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesSkrtic, M., et al. 2011. Cancer Cell 20, 674.
      Olson, M.W., et al. 2006. Antimicrob. Agents Chemother. 50, 2156.
      Stein, G.E., and Craig, W.A., 2006. Clin. Infect Dis. 43, 518.
      Livermore, D.M., 2005. J. Antimicrob. Chemother. 56, 611.